Magnetic Array Enhances Pal-KTTKS Penetration
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Solution Overview
Problem
Current skin care products face challenges in achieving controlled and enhanced penetration of active ingredients, such as Pal-KTTKS, into the skin, with existing methods like chemical penetration enhancers causing irritation and mechanical approaches being costly and inefficient.
Innovation Solution
A cosmetic skin care product featuring a magnetic array with specific dipolar pairs of magnetic poles and a skin care composition containing Pal-KTTKS, utilizing the diamagnetic properties of the active ingredient to enhance penetration through a tailored magnetic field, allowing for controlled depth and amount of penetration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If the amount of active agent in the skin care composition is increased, then the penetration amount into skin is improved, but the formulation stability and sensory feel deteriorate
Solution Approach 1:
The patent replaces chemical penetration enhancers with a magnetic field-based delivery system. The magnetic array generates a magnetic field that interacts with diamagnetic skin care actives, enabling controlled penetration enhancement without increasing active agent concentration or using chemical enhancers that compromise formulation stability.
Solution Approach 2:
The patent changes the physical state or properties of the delivery system by introducing a magnetic field with specific parameters (field strength, gradient, frequency). This allows control over active agent penetration depth and amount without altering the chemical composition or concentration of the active agents themselves.
2Quantity of substance
If chemical penetration enhancers are used to facilitate changes in skin permeability, then the penetration of skin care active is improved, but the risk of adverse side effects increases
Solution Approach 1:
The patent substitutes chemical penetration enhancers with a physical magnetic field-based system. The magnetic array generates a magnetic field that interacts with diamagnetic properties of skin care actives to enhance penetration, eliminating the need for chemical enhancers that cause irritation or adverse side effects.
Solution Approach 2:
The magnetic field acts as an intermediary between the applicator and the skin care active. The magnetic array generates a magnetic field that mediates the delivery process by interacting with the diamagnetic properties of the active agent, enabling controlled penetration without direct chemical interaction that could cause harm.
3Speed
If iontophoresis is used to accelerate charged active agents across skin, then the penetration speed is improved, but the suitability for all target surfaces and barriers deteriorates
Solution Approach 1:
The magnetic array system is designed to be universally applicable to different skin types, areas, and active agents with diamagnetic properties. Unlike iontophoresis which requires specific ionic structures and electrical contact, the magnetic field-based system can be applied to various target surfaces and barriers without requiring intimate electrical contact or adhesive electrodes.
Solution Approach 2:
The patent replaces the electrical field-based iontophoresis system with a magnetic field-based system. This substitution eliminates the limitations of iontophoresis regarding ionic structure requirements and electrical contact needs, making the delivery system more versatile and adaptable to different target surfaces and barriers.
4Quantity of substance
If magnetophoresis techniques are used to create mobility and direction in active agent movement, then the penetration amount is improved, but the hardware requirements and cost increase
Solution Approach 1:
The magnetic array is designed as a simple, cost-effective component that can be integrated into consumer skin care applicators. Rather than requiring complex magnetophoresis hardware systems, the patent uses a straightforward magnetic array configuration that is economical to manufacture and dispose of, making the technology accessible for consumer use.
Solution Approach 2:
The patent extracts and utilizes only the essential magnetic field-generating components needed for penetration enhancement, eliminating unnecessary complex hardware. The magnetic array focuses on the core function of generating a magnetic field with appropriate strength and gradient, removing extraneous systems and reducing overall device complexity and cost.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The magnetic array significantly enhances the delivery of Pal-KTTKS into the skin, providing improved skin care benefits by increasing penetration depth and amount, as demonstrated by the Tape Stripping method, with enhanced delivery ratios compared to passive application.
Implementation Method 1
utilizing the diamagnetic properties of the active ingredient to enhance penetration through a tailored magnetic field
Data Source
Figure 1A
Figure 1B~1C
Figure 1D
AI summary
A cosmetic skin care product that includes an applicator and a skin care composition. The applicator includes a uni-directional magnetic array with a pitch of between 1.7 and 2.5 and a magnetic field strength of between about 24.0 and 36.0 mT. The skin care composition includes palmitoyl-lysine-threonine-threonine-lysine-serine and a dermatologically acceptable carrier. The magnetic array is tailored to enhance penetration of the Pal-KTTKS into skin during application of the skin care composition. The applicator may include a second magnetic array juxtaposed on a first magnetic array to form a bi-directional array that enhances penetration of the Pal-KTTKS into skin.