Magnetic Bead Reagent Mixing by Relative Magnetic Field Motion
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Solution Overview
Problem
Magnetic bead reagents tend to deposit and harden during storage, especially at high concentrations, leading to inefficient manual mixing and reduced test result accuracy, and existing mixing methods such as mechanical rotation or ultrasonic systems are inefficient or impractical.
Innovation Solution
A mixing device comprising a magnetic member, reagent container storage mechanism, and driving mechanism that generates a magnetic field and moves the magnetic bead liquid container relative to the field, allowing for efficient mixing through alternating rotations and orientations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If magnetic bead concentration is increased to improve test result repeatability, then test accuracy is improved, but deposition and hardening of magnetic beads worsens
Solution Approach 1:
The patent applies periodic magnetic field action by alternately reversing the magnetic field direction at set intervals during the mixing process. This periodic reversal prevents magnetic beads from settling and hardening by continuously changing the direction of magnetic force, thereby maintaining bead suspension and preventing deposition even at high concentrations.
Solution Approach 2:
The patent employs dynamic mixing by rotating the magnetic bead container at different speeds and directions while applying magnetic field. This dynamic approach ensures continuous movement of magnetic beads, preventing them from settling and hardening, thus maintaining uniform distribution and preventing deposition issues.
2Object-generated harmful factors
If manual mixing is used to eliminate magnetic bead deposition, then mixing can be performed, but work efficiency deteriorates
Solution Approach 1:
The patent implements automated mixing system where the magnetic bead container is automatically rotated and magnetic field is automatically applied without manual intervention. The system performs mixing operations autonomously, eliminating the need for manual mixing while preventing bead deposition, thus significantly improving work efficiency.
Solution Approach 2:
The patent replaces manual mechanical mixing with an automated system combining magnetic field application and mechanical rotation. This substitution eliminates manual labor while achieving effective mixing, thereby improving productivity and eliminating deposition issues.
3Object-generated harmful factors
If mechanical rotation or ultrasonic system is used to mix magnetic beads, then mixing can be achieved, but device complexity increases
Solution Approach 1:
The patent merges the mixing function with the magnetic field application system. By integrating magnetic field-driven bead movement with container rotation, the system achieves effective mixing without requiring separate ultrasonic or complex mechanical mixing mechanisms, thereby reducing device complexity while preventing deposition.
Solution Approach 2:
The patent uses magnetic field as an intermediary to achieve mixing without direct mechanical contact with magnetic beads. The magnetic field acts as a mediator that moves beads through the liquid medium, avoiding the need for complex mechanical stirrers or ultrasonic systems, thus simplifying the overall device structure.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively mixes magnetic beads without manual intervention, improving efficiency and ensuring accurate test results by changing the direction of magnetic force on the beads, enhancing mixing quality.
Implementation Method 1
at least one magnetic member configured to generate a magnetic field
Implementation Method 2
The direction in which a magnetic force acts on the magnetic beads are changed by the relative movement between the magnetic bead reagent and the magnetic field
Implementation Method 3
The direction in which a magnetic force acts on the magnetic beads are changed by the relative movement between the magnetic bead reagent and the magnetic field, such that the magnetic beads flow in different directions under the action of the magnetic force
Data Source
AI summary
A mixing device for a magnetic bead reagent includes a magnetic member, a container storage mechanism, and a drive mechanism. The container storage mechanism includes a mounting part for mounting a magnetic bead liquid container storing a magnetic bead reagent, and the mounting part corresponds to the magnetic member, enabling the container on the mounting part to be located within the magnetic field. The drive mechanism has a drive structure capable of driving at least one of the magnetic member, the mounting part, and the container to move, and thus generating a relative movement between the container and the magnetic field. The direction of the magnetic force acting on the magnetic beads is changed by the relative movement between the magnetic bead reagent and the magnetic field, such that the magnetic beads flow along different directions under the magnetic force, thereby increasing mixing efficiency of magnetic bead reagent.