Magnetic Cell Surface Binding for Targeted Retention
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Solution Overview
Problem
Current methods lack effective means to bind magnetic particles to mesenchymal cells or chondrocytes for localized drug delivery in regenerative medicine, and there are no established methods to retain these cells at a disease site using external magnetic forces.
Innovation Solution
Development of a magnetic cell with a magnetic particle bound to its surface via a linker or antigen-antibody reaction, allowing for targeted delivery and retention at a disease site using an external magnetic field, incorporating a drug for therapeutic purposes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If magnetic particles are bound to cell surface via linker or antigen-antibody reaction, then magnetic cells can be retained at disease site using external magnetic field, but the complexity of cell preparation and binding mechanism increases
Solution Approach 1:
The patent employs linkers (such as antibodies, peptides, or other binding molecules) as intermediaries to bridge the magnetic particles and cell surface receptors. This intermediary approach enables specific and stable binding of magnetic particles to cells without direct complex interactions, thereby achieving reliable retention at the disease site while managing the complexity of the preparation process through modular binding components.
2Quantity of substance
If magnetic particles are incorporated into cells for localized drug delivery, then drug concentration at target site increases, but the potential harmful effects on cells and surrounding tissues increases
Solution Approach 1:
The patent applies local quality by concentrating the magnetic particles and drugs specifically at the target disease site through external magnetic field guidance, while maintaining normal conditions in surrounding healthy tissues. This spatial differentiation ensures high local drug concentration at the target site for effective therapy, while minimizing harmful effects on surrounding tissues by avoiding unnecessary drug exposure in those areas.
3Duration of action of moving object
If external magnetic field is applied to retain magnetic cells, then cell retention time at disease site is extended, but the complexity of maintaining magnetic field and controlling cell behavior increases
Solution Approach 1:
The patent employs preliminary action by pre-binding magnetic particles to the cell surface before administration to the disease site. This pre-preparation ensures that the cells are already magnetically labeled and ready for retention upon arrival at the target site, reducing the need for complex real-time magnetic field maintenance and control systems during the retention phase.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables the effective retention of magnetic cells at a disease site for extended periods, allowing for localized drug delivery and expression of intrinsic cell functions, applicable in regenerative medicine and cancer therapy.
Implementation Method 1
a magnetic particle which is held on a surface of the cell, and which enables the cell to be moved to a desired location using the magnetism of the magnetic particle
Implementation Method 2
retaining the magnetic cell at the disease site for a long time by means of a magnetic field
Data Source
AI summary
In the present invention, because no examples are known of binding of magnetic particle to mesenchymal cell or chondrocyte which might be used in regenerative medicine, whether or not a cell having the magnetic particle bound thereto is retained in local by external magnetism after administration and whether or not the cell can exhibit intrinsic activity is studied. According to the present invention, a magnetic cell comprising mesenchymal cell or cultured chondrocyte having magnetic particle bound to the surface thereof is provided, and when the cell is administered in vivo and an external magnetic field is applied, the cell can be retained for a long time at a disease site. Moreover, a drug delivery system can be constructed by causing the magnetic cells to contain a drug.