Magnetic Dielectric Particles for Agglomeration-Free Detection

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Solution Overview

Problem

Existing methods for detecting detection target substances using magnetic particles face challenges such as agglomeration during storage, which affects dispersion properties, and metal quenching that reduces signal intensity, leading to inefficient and time-consuming measurements.

Innovation Solution

The use of magnet enveloping dielectric particles with magnetic particles enveloped within dielectrics and modified with functional groups that exhibit polarity, allowing for improved dispersion and separation of magnetic particles, reducing agglomeration and metal quenching, and enabling faster localization and detection of target substances.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If magnetic particles are used for detection, then localization and separation are improved, but agglomeration during storage occurs which deteriorates dispersion properties

Engineering Contradiction:

Improvelocalization and separationVSAvoiddispersion properties

Core Design Contradiction:

Ease of operationVSStability of the object's composition

Solution Approach 1:

The patent embeds magnetic particles within dielectric particles, creating a nested structure where the magnetic particles are contained inside the dielectric matrix. This nesting prevents direct contact between magnetic particles, eliminating agglomeration while preserving magnetic responsiveness for localization and separation operations.

Inventive Principle:

Principle #7Nested doll (Nesting)

Solution Approach 2:

The dielectric material acts as an intermediary between magnetic particles, physically separating them while allowing their magnetic properties to remain functional. The dielectric matrix mediates the interaction between magnetic particles and the external environment, preventing direct magnetic attraction that would cause agglomeration.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Measurement precision

If metal layers are used for surface plasmon enhancement, then signal amplification is improved, but metal quenching occurs which reduces signal intensity

Engineering Contradiction:

Improvesignal amplificationVSAvoidmetal quenching

Core Design Contradiction:

Measurement precisionVSObject-generated harmful factors

Solution Approach 1:

The patent creates a composite structure combining dielectric material with embedded magnetic particles. This composite replaces the traditional metal layer approach, utilizing the dielectric-magnetic composite to achieve signal enhancement through a different mechanism that avoids the harmful metal quenching effect while maintaining measurement precision.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent extracts the magnetic particles from direct contact with the detection environment and embeds them within the dielectric matrix. This extraction removes the source of metal quenching while preserving the magnetic properties needed for particle manipulation and localization, thereby eliminating the harmful effect while maintaining signal amplification capabilities.

Inventive Principle:

Principle #2Taking out (Extraction)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach enhances the practicality of magnetic particle-based detection methods by improving dispersion and agglomeration properties, reducing measurement time, and maintaining signal integrity, allowing for more efficient and accurate detection of target substances.

Implementation Method 1

generating a magnetic field within a sample cell that contains the liquid sample, in which the magnetic property imparted binding substance and the labeling binding substance are mixed, to draw the magnetic property imparted binding substance to a local region within the sample cell

Methodology Applied

Scientific EffectMagnetic field: Magnetic Field

Implementation Method 2

irradiating excitation light only onto a predetermined region that includes the local region, in a state in which the magnetic property imparted binding substance is drawn to the local region, to cause optical signals to be generated by the photoresponsive labels which are present within the predetermined region

Methodology Applied

Scientific EffectFluorescence: Fluorescence

Data Source

PatentUS8456158B2Detecting method and dielectric particles containing magnetic material employed in the detecting method

Publication Date: 2013.06.04 FUJIFILM CORP

AI summary

A magnetic binding substance, which is a first binding substance that specifically binds with a target substance, having magnet enveloping dielectric particles, which have magnetic particles enveloped therein and surfaces modified with functional groups that exhibit polarity within a liquid sample, attached thereto, and a labeling binding substance, which is a second binding substance that specifically binds with the target substance having photoresponsive labels attached thereto, are mixed with the liquid sample such that binding reactions occur. A magnetic field is generated within a sample cell, to draw the magnetic binding substance to a local region. Excitation light is irradiated only onto a predetermined region including the local region while the magnetic binding substance is drawn to the local region, causing the photoresponsive labels present therein to generate optical signals. The optical signals are detected.