Magnetic Drug Administration System for Targeted Cancer Therapy

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Solution Overview

Problem

Conventional anti-cancer drug treatments require prolonged periods, causing significant side effects and reduced efficacy due to cancer tissues developing metabolic resistance, leading to inadequate patient survival ratios and prolonged treatment courses.

Innovation Solution

A system for designing and setting an optimum administration form of magnetic drugs, utilizing a self-magnetic drug with inherent magnetic properties, which includes determining side-effect and drug-efficacy related organs, evaluating and correcting the administration form based on experimental data, and outputting the optimized dosage and administration method to medical personnel.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If a high dose of anti-cancer drug is administered at once, then treatment efficacy is improved, but side effects increase significantly

Engineering Contradiction:

Improvetreatment efficacyVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies local quality by modifying the drug molecule itself to have magnetic properties, enabling spatial differentiation of drug distribution. The magnetic drug concentrates at the target site (cancer tissue) while maintaining lower systemic concentration, thus achieving high local efficacy with reduced systemic side effects

Inventive Principle:

Principle #3Local quality

Solution Approach 2:

The patent introduces a magnetic field as an intermediary to guide and concentrate the drug at the target site. By applying an external magnetic field, the magnetic drug is attracted and retained at the cancer tissue, enabling controlled localization without increasing overall dosage

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If conventional anti-cancer drug treatment is extended over multiple courses, then treatment coverage is improved, but treatment time increases and cancer tissues develop metabolic resistance

Engineering Contradiction:

Improvetreatment coverageVSAvoidtreatment time

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The patent replaces the conventional mechanical/administrative approach of repeated dosing schedules with a magnetic field-based delivery system. This substitution enables single-dose or reduced-course treatment by relying on magnetic retention rather than repeated administration intervals

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent applies preliminary action by pre-modifying the drug molecule with magnetic properties before administration. This preliminary modification enables the drug to be retained at the target site after a single administration, eliminating the need for repeated courses and preventing the development of metabolic resistance

Inventive Principle:

Principle #10Preliminary action

3Reliability

If magnetic drug is administered, then drug retention at affected site is improved, but optimal administration form has not been established

Engineering Contradiction:

Improvedrug retentionVSAvoidadministration form complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies parameter changes by systematically varying administration parameters (magnetic field strength, dosage, application timing) to optimize the administration form. The system determines optimal parameters based on the balance between drug retention at the target site and minimization of side effects

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables effective utilization of magnetic drugs by intensively retaining the drug at the affected site, reducing side effects and enhancing treatment efficacy, allowing for a more focused and efficient anti-cancer treatment without the need for multiple treatment courses.

Implementation Method 1

a system capable of intensively treating an affected site can be realized by administering a magnetic drug and then applying a magnetic field to a target region such as the affected site and guiding the magnetic drug to the target region

Methodology Applied

Scientific EffectMagnetic field interaction: Magnetic Field

Implementation Method 2

a self-magnetic drug developed by inventors of the present application does not use the magnetic element separately from the drug, but uses a drug element which itself has the magnetic property

Methodology Applied

Scientific EffectMagnetic property: Magnetism

Data Source

PatentUS10188344B2Optimum administration form providing system for magnetic drug

Publication Date: 2019.01.29 IHI CORP

AI summary

A system capable of designing an optimum administration form of a magnetic drug is provided. The system determines first information about an side-effect-related organ on which a magnetic drug produces a side effect, based on equipment analysis information after administering the magnetic drug; further determines second information about a drug-efficacy-related organ in which drug efficacy of the magnetic drug should be demonstrated; evaluates the administration form of the magnetic drug based on the first information and the second information; corrects the administration form of the magnetic drug based on an evaluation result; and outputs information of the corrected administration form.