Magnetic Field Control for Specimen Measurement Sensitivity
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Solution Overview
Problem
Conventional specimen measurement devices face challenges in improving reaction efficiency between object materials and magnetic particles in a specimen solution due to the large specific gravity of magnetic particles, which causes them to stay near the sensing area, hindering effective measurement.
Innovation Solution
The device employs a magnetic field application unit with both upward and downward magnetic fields to control the movement of magnetic particles, ensuring they disperse and precipitate within the specimen solution, enhancing their reaction with the object material, and a water-soluble sealing film to facilitate this process.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If magnetic particles are dispersed over the sensing area using a blocking layer, then the magnetic particles can be initially positioned for measurement, but the large specific gravity of magnetic particles causes them to stay near the sensing area, reducing reaction efficiency
Solution Approach 1:
The patent applies dynamic magnetic field control to transition the magnetic particle system from a static dispersed state to a dynamic controlled movement state. By applying external magnetic fields, the magnetic particles are dynamically guided to move away from the sensing area after initial detection, enabling them to circulate and react with target substances in the specimen solution, thus resolving the contradiction between maintaining detection sensitivity and improving reaction efficiency
Solution Approach 2:
The patent changes the magnetic field parameters (strength, direction, timing) to control magnetic particle behavior. Initially, no magnetic field is applied to allow particles to disperse and be detected. After detection, magnetic fields are applied to move particles away from the sensing area. This parameter change enables the system to achieve both high detection sensitivity during measurement and high reaction efficiency during the subsequent particle movement and reaction phases
2Measurement precision
If magnetic particles remain near the sensing area for detection, then measurement can be performed, but the reaction time for magnetic particles to interact with object material increases
Solution Approach 1:
The patent performs preliminary detection of magnetic particles at the sensing area before initiating their movement to reaction zones. This preliminary action allows the system to quickly identify and detect target substances bound to magnetic particles, then immediately trigger magnetic field application to move particles to appropriate reaction areas, thereby reducing overall reaction time while maintaining detection accuracy
Solution Approach 2:
The patent implements periodic cycles of magnetic particle detection, magnetic field application for particle movement, and reaction phases. This periodic action allows the system to repeatedly perform detection and then rapidly transition particles to reaction zones, reducing cumulative reaction time across multiple measurement cycles while preserving detection accuracy during each cycle
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach improves the sensitivity and accuracy of object material detection by ensuring uniform distribution and reaction of magnetic particles, reducing the time required for precipitation and enhancing measurement efficiency.
Implementation Method 1
a magnetic field application unit that generates and applies a magnetic field
Implementation Method 2
a blocking layer containing a water-soluble material
Implementation Method 3
Since the magnetic particles have a relatively large specific gravity, however, they tend to stay near the sensing area
Data Source
AI summary
A specimen measurement device which detects a measurement object material according to the present embodiment, includes: a magnetic field applicator configured to apply a magnetic field to a measurement cartridge including a substrate, a first substance fixed on the substrate and specifically reacting with the measurement object material, a magnetic particle, and a substance fixed on the magnetic particle and specifically acting with the measurement object material; a detector configured to detect light passing through the substrate; and a controller configured to control the magnetic field applicator to perform a first operation to apply a first magnetic field in a direction to move the magnetic particle away from the substrate when a specimen solution containing the measurement object material is introduced into the measurement cartridge, and then perform a second operation to apply a second magnetic field in a direction to move the magnetic particle toward the substrate.