Magnetic Lid Lifter for Microplate Readers
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Solution Overview
Problem
Existing microplate readers face challenges with sample evaporation and gas exchange issues when using lids, leading to inaccurate optical measurements and laborious manual handling, especially in robotic systems where continuous monitoring is required.
Innovation Solution
A microplate reader with an integrated magnetic lid holding apparatus that allows for the automated lifting and replacement of microplate lids, enabling continuous optical measurement and gas exchange while using standard microplates and lids, and allowing for the performance of long-term tests and monitoring of cell cultures.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of substance
If a microplate lid is used to prevent evaporation, then sample loss is reduced, but gas exchange is restricted and optical measurements are impaired
Solution Approach 1:
The patent applies the dynamics principle by implementing an automated lid lifting mechanism that dynamically adjusts the lid position based on measurement requirements. The lid is automatically lifted during optical measurements to ensure accurate readings, then closed between measurements to prevent evaporation. This dynamic adjustment resolves the contradiction between maintaining sample volume and ensuring measurement accuracy.
2Loss of substance
If a microplate lid is used to prevent evaporation, then sample loss is reduced, but gas supply to wells is restricted
Solution Approach 1:
The patent implements periodic action by automatically lifting the lid at scheduled intervals during measurements and closing it between measurements. This periodic opening allows gas exchange to occur at appropriate moments while maintaining evaporation prevention during incubation periods, thus resolving the contradiction between gas supply and evaporation control.
3Reliability
If manual lid removal and replacement is performed, then gas exchange and measurement accuracy are maintained, but labor and time consumption increase
Solution Approach 1:
The patent applies the self-service principle by implementing an automated lid lifting mechanism that operates without manual intervention. The system automatically lifts and closes the lid based on measurement schedules, eliminating the need for manual handling while maintaining measurement accuracy and gas exchange requirements. This resolves the contradiction between measurement reliability and time consumption.
4Extent of automation
If a robotic system is used for automated lid handling, then labor is reduced, but system complexity increases
Solution Approach 1:
The patent extracts the lid lifting function as a separate, dedicated mechanism integrated into the microplate reader, rather than using a complex general-purpose robotic system. This specialized extraction approach provides automated lid handling with minimal additional complexity, resolving the contradiction between automation extent and device complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate and continuous optical measurements, reduces evaporation, maintains gas exchange, and facilitates automated handling of microplates, improving the reliability and efficiency of biological and biochemical tests in microplate readers.
Implementation Method 1
The lid holding apparatus is arranged as a magnetic lifter and comprises a non-array arrangement of at least one permanent magnet, or at least three electro magnets, or at least one switchable permanent magnet
Data Source
AI summary
A microplate reader comprises a housing; at least one optical measuring/detection device; a microplate support; a moving unit; and an integrated lid holding apparatus. The lid holding apparatus is arranged to move the microplate lid and/or the microplate support is arranged to move the microplate in one respective, in an at least approximately vertical direction for moving the microplate lid away from the microplate. The lid holding apparatus is arranged inside the housing as a magnetic lifter and comprises a non-array arrangement of at least one permanent magnet, or at least three electromagnets, or at least one switchable permanent magnet. Each microplate lid to be moved away from the microplate comprises magnetizable material.


