Magnetic Nanoparticle Steering for Non-Invasive Vascular Occlusion Clearing
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Solution Overview
Problem
Current treatments for fluid obstructions in the circulatory system, such as vascular occlusions, face challenges with invasive procedures and side effects from drugs, which can lead to unintended tissue damage and inefficiencies in drug delivery, particularly in low-blood-flow areas.
Innovation Solution
A therapeutic system utilizing a magnet with a magnetic field and gradient to control magnetic rotors within the circulatory system, enhancing the delivery of pharmaceutical compositions like thrombolytic drugs by positioning and rotating the magnetic field to agglomerate and move magnetic nanoparticles, thereby increasing contact with therapeutic targets and improving fluid flow.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If invasive thrombectomy devices are used to remove obstructions, then the obstructions can be physically removed, but unintended tissue damage and secondary damage occur
Solution Approach 1:
The patent replaces mechanical thrombectomy devices with magnetic field-based manipulation of magnetic nanoparticles. Instead of using physical catheters and mechanical retrieval systems that cause vessel wall trauma, the invention uses external magnetic fields to guide and control magnetic nanoparticles infused into the bloodstream, allowing non-invasive obstruction removal while eliminating the need for mechanical contact with blood vessels
Solution Approach 2:
The patent introduces magnetic nanoparticles as an intermediary between the external magnetic field and the blood clot obstruction. These nanoparticles serve as carriers that can be remotely controlled to deliver thrombolytic drugs directly to the obstruction site, enabling precise drug delivery without invasive procedures and minimizing exposure of healthy tissue to harmful drugs
2Productivity
If thrombolytic drugs are administered to dissolve obstructions, then the obstructions can be dissolved, but side effects are difficult to control
Solution Approach 1:
The patent applies local quality by concentrating thrombolytic drugs specifically at the obstruction site through magnetic nanoparticle targeting. Instead of systemic administration that exposes the entire body to drug side effects, the magnetic nanoparticles accumulate preferentially at the clot location under external magnetic field guidance, enabling localized drug action with minimal systemic exposure and reduced side effects
Solution Approach 2:
The patent replaces conventional systemic drug administration with magnetic field-guided targeted delivery. By using external magnetic fields to steer magnetic nanoparticles carrying thrombolytic agents to the obstruction, the system achieves precise drug localization without relying on blood flow distribution, thereby controlling where the drug acts and minimizing off-target side effects
3Object-affected harmful factors
If normal dosages of drugs are used, then systemic exposure is minimized, but the drugs are ineffective in low-blood-flow areas
Solution Approach 1:
The patent employs periodic action through time-varying magnetic fields that oscillate or rotate to enhance nanoparticle accumulation at the obstruction site. By applying alternating magnetic fields that periodically attract and release magnetic nanoparticles, the system creates dynamic accumulation effects that improve drug delivery to low-blood-flow areas over time, overcoming the limitations of static magnetic fields and ensuring effective drug concentration at the target site
Solution Approach 2:
The patent replaces reliance on blood flow for drug delivery with magnetic field-driven nanoparticle transport. In low-blood-flow areas where conventional drugs cannot reach effective concentrations, magnetic nanoparticles are guided by external magnetic fields independent of hemodynamics, enabling effective drug delivery to stagnant or slow-flow regions without increasing systemic drug dosage
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach allows for targeted and efficient delivery of therapeutic agents to obstructed areas, enhancing drug diffusion and fluid flow while minimizing invasive procedures and side effects, effectively clearing blockages without mechanical trauma to vasculature.
Implementation Method 1
a magnet having a magnetic field and a gradient for controlling magnetic rotors in a circulatory system
Implementation Method 2
the controller rotates the magnetic field of the electromagnet by adjusting the electrical current
Implementation Method 3
a magnet having a magnetic field and a gradient for controlling magnetic rotors
Data Source
AI summary
Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one embodiment, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow. Magnetic nanoparticles are provided having a non-specialized chemical coating facilitating association with a chemical composition by a user before infusion. Systems are provided for delivering a consistent infusion mass of magnetic nanoparticles to a patient.