Magnetic Nanoparticle Plaque Clearance via Oscillating Fields

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Solution Overview

Problem

Current methods for removing plaque from arteries are largely invasive, posing risks and lacking effective non-invasive solutions, with a pressing need for a safe and non-invasive method to prevent artery blockages.

Innovation Solution

Introducing polymer-coated superparamagnetic nanoparticles into the bloodstream, guided by an external magnetic field to physically abrade and dislodge plaque deposits, with enzymes on the nanoparticle coating to dissolve or digest disintegrated particles, ensuring safe removal without invasive techniques.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If surgical methods are used to remove plaque, then plaque removal effectiveness is improved, but patient safety and invasiveness worsen

Engineering Contradiction:

Improveplaque removal effectivenessVSAvoidinvasiveness and safety risks

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent replaces mechanical surgical intervention with a magnetic field-based system. Superparamagnetic nanoparticles are introduced into the bloodstream and manipulated by external magnetic fields to reach and remove plaque deposits, substituting invasive mechanical surgery with a non-invasive magnetic manipulation approach

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent uses superparamagnetic nanoparticles as intermediary carriers. These nanoparticles serve as mediators that can be magnetically guided to plaque deposits and then used to physically abrade or chemically dissolve the plaque, enabling remote controlled plaque removal without direct surgical intervention

Inventive Principle:

Principle #24Intermediary (Mediator)

2Object-affected harmful factors

If non-invasive methods are used to remove plaque, then patient safety is improved, but plaque removal effectiveness worsens

Engineering Contradiction:

Improveinvasiveness and safety risksVSAvoidplaque removal effectiveness

Core Design Contradiction:

Object-affected harmful factorsVSProductivity

Solution Approach 1:

The patent employs superparamagnetic nanoparticles whose magnetic properties can be dramatically changed by applying external magnetic fields. This allows the nanoparticles to be attracted to and accumulate at plaque deposits on demand, providing strong localized magnetic forces for effective plaque removal while maintaining non-invasive administration

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent utilizes oscillating magnetic fields to induce mechanical vibration in the superparamagnetic nanoparticles. This vibration enables the nanoparticles to physically abrade plaque deposits through repeated impact, providing a mechanical plaque removal mechanism that is non-invasive yet effective

Inventive Principle:

Principle #18Mechanical vibration

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The method effectively removes plaque deposits from arteries, preventing blockages and rejuvenating the circulatory system through non-invasive means, allowing for both emergency and routine maintenance of arterial health.

Implementation Method 1

magnetic nanoparticles are manipulated to the location of a tumor through the human vascular system, where the chemotherapy drugs may be released in a specific target area

Methodology Applied

Scientific EffectMagnetic field manipulation: Magnetic Field

Implementation Method 2

introducing a plurality of polymer-coated superparamagnetic nanoparticles into the bloodstream

Methodology Applied

Scientific EffectSuperparamagnetism: Superparamagnetism

Implementation Method 3

the nanoparticles are heated by magnetic induction to a sufficient temperature to kill cancer cells in the proximity of the heated nanoparticles

Methodology Applied

Scientific EffectMagnetic induction heating: Electromagnetic Induction

Implementation Method 4

vibrate the nanoparticles in proximity of a plaque deposit to physically abrade and dislodge the plaque deposit

Methodology Applied

Scientific EffectMechanical vibration: Vibration

Implementation Method 5

with enzymes on the nanoparticle coating to dissolve or digest disintegrated particles

Methodology Applied

Scientific EffectEnzymatic digestion: Enzyme

Data Source

PatentUS20220203113A1Magnetic nanoparticle plaque clearance

Publication Date: 2022.06.30 CASTOR TREVOR P

AI summary

This invention relates to methods and systems for removing plaque from arteries and blood vessels in human subjects non-invasively utilizing coated superparamagnetic nanoparticles introduced into the human bloodstream and controlled by external magnetic fields to effect plaque removal. Magnetic nanoparticles are injected into a patient, and magnetic fields are used to move the nanoparticles to the site of an arterial blockage. The nanoparticles are then oscillated by means of an alternating current source and oscillating magnetic field. The nanoparticles impact the plaque deposit, causing it to break up, so that it may be safely disintegrated, dissolved in the bloodstream, digested by enzymes or ions and/or removed with the nanoparticles themselves. The nanoparticles are removed by a unipolar magnetic field directing them to be removed at the point of injection or alternative location in the body. The nanoparticles are also removed by natural bodily functions. The methods and systems are directed to the emergency clearance of arteries in the human body, and the routine annual and quarterly clearance and preventative maintenance of arteries in the human body.