Magnetic Organ Chip Actuation Without Vacuum Membrane Damage
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Solution Overview
Problem
Traditional organ chips used for simulating in vivo physiological environments face issues such as membrane damage due to vacuum systems, complex manufacturing, and high costs, which hinder accurate parameter control and efficiency.
Innovation Solution
A bionic organ device utilizing a magnetically-driven flexible body and a magnetic field generating module to simulate dynamic microenvironments, eliminating the need for vacuum systems and simplifying the structure for streamlined manufacturing and reduced costs.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a vacuum system is used to simulate dynamic microenvironment and achieve stretching effects, then the bionic effect is improved, but the membrane may be damaged and the device complexity increases
Solution Approach 1:
The patent replaces the vacuum system with a magnetic field generating module that uses magnetic forces to deform the flexible body, thereby substituting a mechanical system with a magnetic field-based system to avoid membrane damage while achieving the same stretching effect
Solution Approach 2:
The patent introduces a magnetically-driven flexible body as an intermediary between the magnetic field generating module and the porous membrane, allowing magnetic forces to indirectly control the membrane deformation without direct contact, thus preventing membrane damage
2Ease of manufacture
If a vacuum system is used to achieve stretching effects, then the bionic effect is improved, but the manufacturing complexity and cost increase
Solution Approach 1:
The patent replaces the complex vacuum system with a simpler magnetic field generating module, reducing manufacturing complexity and cost while maintaining the ability to achieve stretching effects through magnetic field application
3Ease of operation
If a vacuum system is used to simulate dynamic microenvironment, then the physiological function simulation is improved, but the operation convenience decreases
Solution Approach 1:
The patent replaces the vacuum system with a magnetic field generating module, improving operation convenience by eliminating the need for vacuum control while maintaining the ability to accurately simulate physiological functions through magnetic field-induced flexible body deformation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively simulates the dynamic microenvironment of organs and tissues, offering improved convenience, reduced costs, and enhanced manufacturing efficiency by using a simplified structure.
Implementation Method 1
the magnetic field passes through the at least one magnetically-driven flexible body and causes the at least one magnetically-driven flexible body to deform in response to a magnetic force in the magnetic field
Data Source
AI summary
A bionic organ device includes an organ chip and a magnetic field generating module. The organ chip includes a first body, a second body, a porous membrane, and a magnetically-driven flexible body. The porous membrane is disposed between the first body and the second body and forms a channel system with the first body and the second body. The at least one magnetically-driven flexible body is disposed in the first body, the second body, or a combination thereof, and is adjacent to the channel system. The magnetic field generating module is disposed outside the organ chip and is adapted to generate a magnetic field. The magnetic field passes through the at least one magnetically-driven flexible body and causes the at least one magnetically-driven flexible body to deform in response to a magnetic force in the magnetic field.