Magnetic Particulate Delivery for Pelvic Tissue Targeting
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Solution Overview
Problem
Current treatments for pelvic disorders such as erectile dysfunction, urinary and fecal incontinence, and uterine health issues are often invasive, ineffective, or have significant side effects, and there is a need for minimally invasive and durable solutions that can target specific areas within the pelvic region with minimal side effects.
Innovation Solution
The use of magnetic particulates associated with cells or drugs, delivered via a system that includes a magnetic field-generating device to position and retain the particulates within pelvic tissues, allowing for localized treatment of conditions like erectile dysfunction, urinary and fecal incontinence, prolapse, and uterine health issues.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If oral medications are taken for treating ED, then relief is provided to a large segment of men with ED, but the medication must be taken in advance of initiation of sexual activity and effects may be delayed if ingested with food
Solution Approach 1:
The patent replaces the gastrointestinal absorption pathway with a direct urethral delivery system. The medication is administered as a suppository or injection through the urethra, bypassing the digestive system and achieving rapid onset of action without food interference or delayed absorption.
Solution Approach 2:
The urethra serves as an intermediary delivery route, allowing direct access to the bloodstream and erectile tissues. This intermediate pathway enables rapid drug delivery without requiring advance preparation or being affected by food intake.
2Reliability
If surgical interventions such as penile implants are used to address ED, then patient sexual satisfaction is restored, but implants may fail over time and replacement or total removal may be required
Solution Approach 1:
The patent employs biodegradable polymers that temporarily support erectile function and then naturally degrade in the body. This eliminates the need for permanent implants that can fail, requiring removal or replacement surgery. The temporary scaffold provides structural support during the treatment period and then safely disappears.
Solution Approach 2:
The patent changes the physical and chemical parameters of the treatment material over time. The biodegradable polymer starts with specific mechanical properties to support erection, then gradually degrades as it performs its function, transforming from a structural support material to a resorbable byproduct without requiring surgical intervention.
3Measurement precision
If magnetic particulates are delivered via injection into pelvic tissue, then targeted and effective delivery of therapeutic agents is achieved, but the system requires a magnetic field-generating device for positioning
Solution Approach 1:
The magnetic field-generating device is designed to perform multiple functions: it positions the magnetic particulates, maintains them at the target site, and can be removed after treatment. This multi-functional approach reduces the need for multiple separate devices and simplifies the overall treatment system while maintaining high targeting precision.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables targeted and effective delivery of therapeutic agents directly to affected areas, enhancing regenerative opportunities and improving treatment outcomes with reduced side effects and increased durability compared to existing methods.
Implementation Method 1
The device comprises a member capable of providing a magnetic field which influences the positioning of the magnetic particulates within the pelvic tissue
Data Source
AI summary
Systems and methods of localizing or delivery cells, biologics and/or drugs to a specific target area to treat pelvic health disorders are provided. A treatment composition including cells, biologics and/or drugs are associated with magnetic particulates, and the positioning of these materials is facilitated through use of a magnetic field-generating device that is configured to be placed on or into a pelvic anatomical structure. Certain embodiments directed to the treatment of ED in male patients can include a cell based therapy system.