Magnetic Solid-Phase Extraction Device Framework Design
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Solution Overview
Problem
Existing automatic devices for biological sample pre-treatment, particularly those using magnetic solid-phase extraction, face challenges such as limited automation, large space requirements, and environmental pollution due to nitrogen blowing, making them semi-automated and inefficient.
Innovation Solution
A fully automatic magnetic solid-phase extraction device with a framework assembly that includes a platform for functional devices like sample strips, consumable stations, pipettes, transport, oscillation, and magnetic frames, utilizing an X-axis moving assembly and oscillation mechanism to simplify the extraction process, reduce space requirements, and prevent pollution.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If liquid-liquid extraction method is used with centrifugation, then solid-liquid separation is achieved, but device volume increases and automation is limited
Solution Approach 1:
The patent extracts the centrifugation function and replaces it with magnetic solid-phase extraction. The magnetic beads capture target substances directly in solution without requiring centrifugal force, eliminating the need for centrifuge equipment and reducing device volume while maintaining effective separation.
Solution Approach 2:
The patent replaces the mechanical centrifugation system with a magnetic field-based separation system. Magnetic beads respond to magnetic fields for separation instead of requiring mechanical rotation, enabling automation and reducing equipment complexity.
2Adaptability or versatility
If solid-phase extraction SPE module and magnetic solid-phase extraction module coexist, then extraction capability is enhanced, but device complexity and space requirements increase
Solution Approach 1:
The patent integrates multiple extraction capabilities into a single magnetic solid-phase extraction module. The system can perform different extraction operations using magnetic beads with various functional groups, eliminating the need for separate SPE and MSPE modules while maintaining versatility.
Solution Approach 2:
The patent combines the functions of solid-phase extraction and magnetic solid-phase extraction into one integrated module. The magnetic beads serve both as the extraction medium and the separation mechanism, merging what would traditionally require two separate modules into a single compact unit.
3Productivity
If liquid-liquid extraction is used with nitrogen blowing, then extraction efficiency is improved, but environmental pollution occurs
Solution Approach 1:
The patent eliminates the need for nitrogen blowing by using magnetic solid-phase extraction. The magnetic beads directly capture target substances from solution without requiring evaporation or concentration steps that generate toxic gases, converting a potentially harmful process into a clean, environmentally friendly operation.
4Productivity
If single plate extraction is used, then processing capacity is limited, but device simplicity is maintained
Solution Approach 1:
The patent transitions from single-plate processing to multi-plate or high-throughput plate processing capability. The automated magnetic solid-phase extraction system can handle multiple plates simultaneously or sequentially, expanding processing capacity in the vertical dimension of automation without proportionally increasing device complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device achieves full automation, reduces processing costs, and improves efficiency by enabling independent operation of processes, with a compact design that addresses space and pollution issues, and includes features like automatic oscillation and pipette functions for enhanced stability and functionality.
Implementation Method 1
a magnetic field assembly (206) below the oscillation assembly (205), wherein the magnetic field assembly (206) is used for magnetic bead method extraction
Data Source
AI summary
The present invention provides a device capable of conducting magnetic solid-phase extraction, including a framework assembly. The framework assembly includes a platform assembly and an electrical cabinet assembly. The electrical cabinet assembly is disposed below the platform assembly, and an electric assembly is packaged in an electrical cabinet of the electrical cabinet assembly. The electric assembly is disposed independent from the platform assembly. Data wires connected to the electric assembly and the platform assembly are placed in the framework frame or a sheet metal structure, preventing reagents and operations on the platform assembly from polluting or affecting the electric assembly. The present invention designs a magnetic solid-phase extraction device. Pretreating samples in a manner of magnetic solid-phase extraction simplifies the extraction process, reduces the processing costs of the device, and overcomes negative effects caused by some other extraction methods in the background.