Magnetic Transfer Probe Convex Bottom for Particle Collection

The patent employs a magnet with a convex bottom portion (spheroidal curvature) instead of a flat bottom. This curved geometry concentrates magnetic field lines at the bottom surface, significantly enhancing the magnetic field gradient in the region where particle collection occurs. The convex shape creates a focal point for magnetic flux, thereby increasing the collecting force on magnetically responsive particles without requiring additional complex structures.

The patent implements a two-stage process: first, magnetically responsive particles are pre-bound to the target substance in the composition; second, the magnetic transfer probe selectively collects these particle-target complexes. This preliminary binding action allows the target substance to be pre-concentrated on the particles before magnetic collection, enabling efficient processing of smaller volumes while maintaining high recovery yields. The probe only needs to collect the particle complexes rather than separating target molecules directly from large volumes.

The patent employs a movable magnet mechanism within the transfer probe, allowing the magnet's position to be dynamically adjusted relative to the shield opening. During the collection phase, the magnet is positioned close to the vessel bottom for efficient particle collection in small volumes. During the release phase, the magnet is retracted or moved away from the opening, reducing the magnetic field strength at the release point and enabling easy particle discharge. This dynamic positioning resolves the contradiction between collection efficiency and release ease.