Magnetizable Particles for Non-Invasive Deep Brain Stimulation

Solution Overview

Problem

Current treatments for addictive and neurological disorders often require invasive deep brain stimulation, which can be risky and inconvenient for patients.

Innovation Solution

A non-invasive method using magnetizable particles introduced into the body via nasal administration or other non-invasive means, guided by image-guidance components to target specific brain structures, and activated by magnetic or electromagnetic fields to modulate neuronal function.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If invasive deep brain stimulation is used to treat addictive and neurological disorders, then effective treatment can be achieved, but the procedure becomes risky and inconvenient for patients

Engineering Contradiction:

Improvetreatment effectivenessVSAvoidinvasiveness and risk

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

Magnetizable particles serve as intermediaries that can be introduced non-invasively into the brain and then manipulated by external magnetic fields to achieve deep brain stimulation effects. The particles mediate between the external magnetic field application and the neuronal tissue, enabling treatment without direct invasive stimulation electrodes

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent replaces the mechanical invasive procedure of inserting stimulation electrodes with a non-invasive magnetic field-based system. Instead of mechanically penetrating the brain with electrodes, the system uses magnetic fields to manipulate magnetizable particles that have been introduced through non-invasive routes, substituting mechanical invasion with electromagnetic manipulation

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

2Reliability

If invasive deep brain stimulation is used to treat addictive and neurological disorders, then effective treatment can be achieved, but the procedure becomes inconvenient for patients

Engineering Contradiction:

Improvetreatment effectivenessVSAvoidpatient convenience

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

Magnetizable particles serve as intermediaries that can be introduced non-invasively into the brain and then manipulated by external magnetic fields to achieve deep brain stimulation effects. The particles mediate between the external magnetic field application and the neuronal tissue, enabling treatment without direct invasive stimulation electrodes

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent replaces the mechanical invasive procedure of inserting stimulation electrodes with a non-invasive magnetic field-based system. Instead of mechanically penetrating the brain with electrodes, the system uses magnetic fields to manipulate magnetizable particles that have been introduced through non-invasive routes, substituting mechanical invasion with electromagnetic manipulation

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach allows for effective deep brain stimulation without the need for invasive procedures, providing a safer and more convenient treatment option for addiction and other neurological disorders.

Implementation Method 1

at least one image-guidance component located in proximity to the one or more body structures may be used to direct, transport, concentrate and/or focus the one or more particles within the one or more body structures within a subject

Methodology Applied

Scientific EffectMagnetic field: Magnetic Field

Implementation Method 2

at least one activation component may be used to cause the one or more particles to modulate neuronal function in the one or more body structures within a subject

Methodology Applied

Scientific EffectMagnetic field: Magnetic Field

Implementation Method 3

activated by magnetic or electromagnetic fields to modulate neuronal function

Methodology Applied

Scientific EffectElectromagnetic field: Electromagnetic Induction

Data Source

PatentUS11357997B2Equipment and methodolgies for non-invasive treatment for addiction

Publication Date: 2022.06.14 WEINBERG MEDICAL PHYSICS INC

AI summary

Methodologies and mechanisms are provided for introducing one or more magnetizable particles introduced non-invasively into one or more body structures containing nervous tissue in a subject, directing, guiding, transporting, focusing and/or concentrating the one or more particles using at least one image-guidance component in proximity to the one or more body structures which can direct the one or more particles within the one or more body structures, and modulating, using at least one activation component, the one or more particles to modulate neuronal function in the one or more body structures of the subject.