Magnetized Cell Iron Oxide Threshold Magnetic Guidance
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Solution Overview
Problem
It is unclear under what conditions a cell can be magnetized to be efficiently guided and retained at a desired position using a magnetic field for magnetic targeting applications.
Innovation Solution
A magnetized cell containing iron oxide with an iron content of at least 35 pg/cell, when subjected to a magnetic field with a flux density of 0.1 T, can be effectively guided and retained at a desired position, utilizing superparamagnetic iron oxide coated with water-soluble polysaccharides like ferucarbotran, and applied using a solenoid coil for efficient magnetic field generation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If magnetic particles are applied to cells for magnetic targeting, then cells can be guided to desired position, but it is unclear under what condition to magnetize a cell for efficient guidance and retention
Solution Approach 1:
The patent establishes specific parameter thresholds for effective magnetic targeting: iron content of not less than 35 pg/cell and magnetic flux density of not less than 0.1 T. By defining these critical parameters, the invention transforms the unclear conditions into quantifiable guidelines that ensure both precise guidance and reliable retention of magnetized cells at target sites.
2Ease of operation
If iron oxide is introduced into cells to enable magnetic guidance, then cell guidance becomes possible, but the optimal iron content for efficient guidance remains undefined
Solution Approach 1:
The patent identifies a critical threshold of 35 pg/cell for iron content in magnetized cells. This parameter specification optimizes the balance between guidance efficiency and material quantity, ensuring that sufficient iron oxide is present for effective magnetic manipulation while avoiding excessive amounts that could burden the cell system.
3Force
If a magnetic field is applied to guide magnetized cells, then cells can be directed to target position, but the magnetic flux density required for effective retention is not established
Solution Approach 1:
The patent establishes a magnetic flux density threshold of not less than 0.1 T as the minimum requirement for effective cell retention. This parameter definition ensures that sufficient magnetic force is applied to maintain cells at the target position while providing a clear operational guideline that avoids unnecessarily high energy consumption associated with stronger magnetic fields.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach allows for the efficient guidance and retention of magnetized cells at injury sites, such as knee cartilage injuries, facilitating targeted rehabilitation with quicker accumulation and reduced dispersal, enhancing the effectiveness of magnetic targeting techniques.
Implementation Method 1
applying a magnetic field to magnetized cells, obtained by combination of cells and magnetic particles
Implementation Method 2
a magnetized cell in accordance with an aspect of the present invention contains iron oxide, the magnetized cell containing iron, derived from the iron oxide
Data Source
AI summary
Provided is a technique that makes it possible to efficiently guide a magnetized cell by application of a magnetic field. The magnetized cell contains iron oxide, the magnetized cell containing iron, derived from the iron oxide, in an amount of not less than 35 pg/cell.