Maize PH4D9B Breeding via Marker-Assisted Selection

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Solution Overview

Problem

The development of new maize varieties and hybrids is a time-consuming process, taking six to twelve years, and existing technologies face challenges in combining desirable traits such as disease resistance, drought tolerance, and high yield in a stable and agronomically sound manner.

Innovation Solution

The introduction of the novel maize variety PH4D9B, which involves specific breeding techniques including backcross conversion, genetic manipulation, and transformation to incorporate traits like male sterility, disease resistance, and improved agronomic characteristics, along with processes for producing hybrid seeds through controlled pollination and tissue culture.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional breeding methods are used to develop new maize varieties, then desirable traits such as disease resistance and high yield can be combined, but the process takes six to twelve years which is time-consuming

Engineering Contradiction:
Improvestability of desirable traitsVSAvoidbreeding cycle duration
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The patent employs preliminary action by using molecular markers to identify and select plants with desired traits at early stages of breeding, rather than waiting for full maturation and trait expression. This allows breeders to make selection decisions earlier in the breeding cycle, significantly reducing the time required to develop new varieties while maintaining trait stability through marker-assisted selection

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent replaces traditional mechanical/phenotypic selection methods with molecular marker-based selection systems. Instead of visually assessing traits in mature plants, the invention uses DNA markers to detect and select for desirable genetic characteristics at the molecular level, accelerating the breeding process while ensuring reliable trait inheritance

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Adaptability or versatility

If multiple desirable traits are combined in a single variety through traditional breeding, then agronomic soundness improves, but the complexity of the breeding program increases

Engineering Contradiction:
Improveagronomic soundnessVSAvoidbreeding program complexity
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent applies segmentation by breaking down the complex task of combining multiple traits into manageable segments using molecular markers. Each desired trait is associated with specific marker profiles, allowing breeders to independently track and select for each trait segment. This modular approach simplifies the overall breeding program complexity while achieving comprehensive trait combination

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent implements universality by developing a standardized molecular marker system that can be applied across multiple breeding programs and trait combinations. The marker-assisted selection methodology serves multiple functions: identifying desired traits, tracking inheritance patterns, and predicting performance outcomes, thereby reducing program complexity through a universal toolset applicable to various breeding objectives

Inventive Principle:
Principle #6Universality (Multi-functionality)

3Productivity

If molecular markers are used to accelerate variety development, then breeding time is reduced, but the cost and technical complexity of the process increases

Engineering Contradiction:
Improvebreeding speedVSAvoidmolecular marker system complexity
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The patent applies parameter changes by optimizing molecular marker selection criteria and threshold values to achieve maximum breeding acceleration with minimum system complexity. By carefully selecting markers that are highly informative and easily detectable, the invention achieves high productivity while keeping the molecular system relatively simple and cost-effective

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent implements self-service by developing molecular marker systems that can be implemented by breeding programs themselves without requiring extensive external technical support. The methodology is designed to be self-contained, with standardized protocols that breeding teams can execute independently, thereby achieving high productivity while minimizing the need for complex external infrastructure

Inventive Principle:
Principle #25Self-service

Data Source

PatentUS11622518B1Maize inbred PH4D9B
Publication Date: 2023.04.11 PIONEER HI BREED INTERNATIONAL INC

AI summary

A novel maize variety designated PH4D9B and seed, plants and plant parts thereof are provided. Methods for producing a maize plant comprise crossing maize variety PH4D9B with another maize plant are provided. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH4D9B through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby are provided. Hybrid maize seed, plants or plant parts are produced by crossing the variety PH4D9B or a locus conversion of PH4D9B with another maize variety.