Maltodextrin Urolithin Inclusion Complexes for Aqueous Solubility
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Solution Overview
Problem
Urolithins have poor aqueous solubility, making it challenging to develop effective formulations for their administration, particularly for improving muscle function and other health benefits.
Innovation Solution
The development of aqueous formulations comprising urolithins and maltodextrin, specifically agglomerated maltodextrin, which enhances the solubility and bioavailability of urolithins, allowing for their administration in beverages such as sports drinks.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If urolithins are used in aqueous formulations, then health benefits and muscle function improvement are achieved, but solubility is insufficient leading to poor bioavailability
Solution Approach 1:
The patent uses maltodextrin as a solubility-enhancing agent that acts as an intermediary between urolithins and water. The maltodextrin forms inclusion complexes with urolithins, where the hydrophobic urolithin molecules are encapsulated within the hydrophilic maltodextrin structure, enabling aqueous solubility while maintaining urolithin stability and bioavailability.
Solution Approach 2:
The patent creates a composite formulation consisting of urolithins combined with maltodextrin. This composite material combines the therapeutic properties of urolithins with the solubility-enhancing properties of maltodextrin, resulting in a formulation that achieves both health benefits and adequate solubility for effective delivery.
2Reliability
If urolithins are administered directly, then therapeutic effects are achieved, but poor solubility limits effective delivery
Solution Approach 1:
Maltodextrin serves as a mediator that simplifies formulation by providing a straightforward solubility enhancement mechanism. The inclusion complex formation between maltodextrin and urolithins is a well-established process that does not require complex manufacturing steps, making the formulation easy to manufacture while ensuring reliable therapeutic delivery.
3Quantity of substance
If solubility is enhanced using conventional methods, then aqueous delivery is improved, but bioavailability remains insufficient
Solution Approach 1:
The maltodextrin inclusion complex acts as a specialized intermediary that simultaneously addresses both solubility and bioavailability. The complex structure protects urolithins from degradation in the gastrointestinal tract while maintaining their molecular integrity for absorption, thereby achieving both high solubility and high bioavailability.
Solution Approach 2:
The patent changes the physical state and molecular environment of urolithins by incorporating them into maltodextrin complexes. This parameter change transforms urolithins from poorly soluble crystalline molecules to soluble complexed forms, improving both solubility and bioavailability through modification of physical-chemical parameters.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The maltodextrin-based formulations significantly improve the solubility and bioavailability of urolithins, enabling effective delivery and absorption, thereby enhancing muscle function and overall health benefits.
Implementation Method 1
maltodextrin, for example, agglomerated maltodextrin
Data Source
AI summary
Disclosed are aqueous formulations comprising urolithins particularly water-based formulations comprising urolithins and maltodextrin. Also disclosed are compositions for admixture with water, methods for the preparation of such aqueous formulations, and to the uses of such formulations for both the treatment of diseases, disorders and conditions, for example, diseases disorders or conditions characterized by inadequate mitochondrial function and for administration to generally healthy individuals for example, for improving health and improving muscle function and performance.