Mannose-6-phosphate Mannose Mixture Anti-Aging

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Solution Overview

Problem

Current cosmetic products are inadequate in effectively addressing the visible signs of skin aging, such as wrinkles and age spots, by failing to adequately target the structural framework of the skin, specifically the extracellular matrix.

Innovation Solution

A cosmetic active agent comprising a mixture of mannose-6-phosphate and mannose in a specific molar ratio (3:1 to 0.3:1) is used to reduce the visible signs of aging by promoting collagen production, restructuring the extracellular matrix, and enhancing mitochondrial energy metabolism.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional cosmetic products are used, then skin moisturizing and basic care are provided, but the visible signs of aging such as wrinkles and age spots are not effectively reduced

Engineering Contradiction:

Improveeffectiveness in reducing visible signs of agingVSAvoidability to target and restructure extracellular matrix

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The patent changes the chemical parameters by introducing mannose-6-phosphate and mannose in specific molar ratios (3:1 to 0.3:1), which fundamentally alters the biological activity of the cosmetic composition, enabling it to target and restructure the extracellular matrix and reduce visible signs of aging effectively

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates a composite active agent combining mannose-6-phosphate and mannose in specific proportions, where the synergistic interaction between these two components enables enhanced mitochondrial energy metabolism and extracellular matrix restructuring, achieving superior anti-aging effects compared to single ingredients

Inventive Principle:

Principle #40Composite materials

2Adaptability or versatility

If cosmetic products focus on outer skin layer care, then basic moisturizing is achieved, but the structural framework of the skin including extracellular matrix is not adequately addressed

Engineering Contradiction:

Improveability to target multiple skin layers and structuresVSAvoidmechanism of action complexity

Core Design Contradiction:

Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The mannose-6-phosphate and mannose mixture serves multiple functions simultaneously: it enhances mitochondrial energy metabolism, promotes collagen production, restructures the extracellular matrix, and improves skin elasticity, making it a universal active agent that addresses both surface and deep structural skin concerns

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent uses mannose-6-phosphate and mannose as intermediary substances that mediate between external cosmetic application and internal skin cell processes, enabling the formulation to influence mitochondrial function and extracellular matrix structure from the outside

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The mixture significantly reduces wrinkles, age spots, and improves collagen fiber organization, leading to a more youthful appearance and enhanced skin elasticity, as confirmed by in vitro, ex vivo, and clinical studies.

Implementation Method 1

enhancing mitochondrial energy metabolism

Methodology Applied

Scientific EffectCellular respiration:

Implementation Method 2

promoting collagen production

Methodology Applied

Scientific EffectProtein synthesis:

Implementation Method 3

restructuring the extracellular matrix

Methodology Applied

Scientific EffectExtracellular matrix restructuring:

Data Source

PatentUS12290587B2Anti-aging cosmetic compositions

Publication Date: 2025.05.06 GIVAUDAN SA

AI summary

A cosmetic active agent comprising a mixture of mannose-6-phosphate and mannose is disclosed.