High Resolution Manometry for Rectal and Esophageal Disease Detection
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Solution Overview
Problem
Current methods for detecting rectum and esophagus diseases using high resolution manometry face limitations in accuracy and reliability, particularly in analyzing pressure and impedance values, which affect the efficiency of disease determination.
Innovation Solution
The method involves obtaining pressure values from multiple sensors to create a three-dimensional pressure distribution, calculating volume integral values for specific sections, and comparing these values to predetermined thresholds to determine diseases such as constipation and fecal incontinence, while for esophagus diseases, impedance values are converted to conductance and analyzed in a three-dimensional conductance distribution to improve diagnostic efficiency.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If a representative value or average value among all sensor values in manometry is used, then the analysis process is simplified, but the accuracy and reliability of disease determination deteriorates
Solution Approach 1:
The patent divides the manometry data into multiple sections along the catheter length, with each section containing multiple sensors. Instead of using a single representative or average value, the system analyzes pressure distribution across multiple discrete sections, allowing for localized disease detection while maintaining systematic analysis structure.
Solution Approach 2:
The patent transitions from one-dimensional sensor readings to three-dimensional pressure distribution by incorporating spatial position (catheter location), temporal data (pressure changes over time), and multiple sensor readings across different sections. This multi-dimensional approach enables comprehensive disease characterization without oversimplifying the data.
2Device complexity
If sensors are arranged at intervals of 5 centimeters in conventional manometry, then the device complexity is reduced, but the measurement precision for detecting esophagus disease deteriorates
Solution Approach 1:
The patent segments the esophagus into multiple measurement sections along the catheter, with each section containing multiple sensors spaced at 1 cm intervals. This segmentation allows dense sampling for high precision detection while organizing the complex data into manageable sections that can be processed systematically.
Solution Approach 2:
The patent applies different sensor densities to different regions of the esophagus based on clinical needs. The high-resolution 1 cm spacing is applied to critical areas where disease detection is most important, while the overall system architecture maintains manageable complexity through standardized section-based organization.
3Adaptability or versatility
If impedance test method is used to detect gastroesophageal reflux disease, then the indirect resistance measurement provides useful information, but the accuracy and reliability of disease verification deteriorates due to lack of objective numbers
Solution Approach 1:
The patent introduces conductance as an intermediary parameter that converts impedance measurements into more interpretable values. By transforming impedance data into conductance distributions and calculating volume integral values, the system creates objective quantitative metrics that directly correlate with disease presence, bridging the gap between indirect resistance measurement and reliable disease verification.
Solution Approach 2:
The patent changes the measurement parameter from impedance to conductance, and further transforms it into volume integral values through integration across three-dimensional space. This parameter transformation converts subjective resistance measurements into objective, quantifiable disease indicators, significantly improving verification accuracy while maintaining the versatility of indirect measurement.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enhances the determination efficiency of rectum and esophagus diseases by providing more accurate and reliable diagnostic results through advanced data processing and threshold comparisons, improving the accuracy of disease diagnosis compared to conventional methods.
Implementation Method 1
A anorectal manometry inserts manometry, which a plurality of pressure sensors are disposed, into anus and obtain pressure value
Implementation Method 2
an impedance test method that is limitedly used to verify a gastroesophageal reflux disease is noticed by an idea that amount of bolus swallowed through esophagus is detected by indirect resistance
Data Source
AI summary
A method for detecting disease using a manometry includes obtaining pressure values from each of the plurality of pressure sensors during a pre-set time, obtaining a three-dimensional pressure distribution showing the changes in the pressure values according to location and time by using the time, the pressure values, and locations in which the pressure sensors are disposed within the arbitrary location section, and calculating the volume integral value of the interest location which is predetermined in accordance with the disease, in the three-dimensional pressure distribution.