Heat-Treated Marine Collagen Extract for Epidermolysis Bullosa
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Solution Overview
Problem
Current treatments for Epidermolysis Bullosa (EB) are inadequate, as they face challenges such as limited availability of mammalian collagen sources, risks of disease transmission, high costs, and inefficacy in penetrating intact skin, leading to complications like Squamous Cell Carcinoma and lack of effective gene modulation.
Innovation Solution
A heat-treated collagenous marine invertebrate extract, particularly from jellyfish, is used to upregulate key genes associated with EB, enhancing dermal cohesion and extracellular matrix synthesis, thereby improving skin integrity and reducing blistering.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If mammalian collagen sources are used for EB treatment, then the treatment can provide collagen for skin repair, but the availability is limited and disease transmission risks arise
Solution Approach 1:
The patent uses marine invertebrate collagen as an intermediary substance that can fulfill the therapeutic function of mammalian collagen without the associated risks. The marine collagen extract serves as a mediator that provides the necessary collagen for skin repair while eliminating the disease transmission risks and availability constraints of mammalian sources
Solution Approach 2:
The patent creates a functional copy of mammalian collagen using marine invertebrate sources. The marine collagen extract replicates the essential properties and functions of mammalian collagen needed for EB treatment, providing the same therapeutic benefits without the drawbacks of the original mammalian sources
2Reliability
If mammalian collagen is used for EB treatment, then collagen can be provided for skin repair, but the cost becomes very high
Solution Approach 1:
The patent employs marine invertebrate collagen as a more economical alternative to expensive mammalian collagen. The marine collagen extract provides the necessary therapeutic effects at a lower cost, making the treatment more accessible and economically viable while maintaining effectiveness
3Ease of operation
If topical collagen treatment is applied to intact skin, then the treatment should reach the affected layers, but the collagen cannot penetrate intact skin
Solution Approach 1:
The patent modifies the properties of collagen through heat treatment to create a collagen extract that can penetrate intact skin. By changing the physical and chemical parameters of collagen through heating, the treatment achieves effective penetration through the skin barrier while maintaining the ability to reach affected layers and provide therapeutic benefits
4Ease of operation
If current EB treatments are used, then some symptom management is achieved, but gene modulation is ineffective and complications like SCC occur
Solution Approach 1:
The marine collagen extract acts as a mediator that not only provides structural support for symptom management but also triggers gene modulation effects. The extract serves dual functions: managing current symptoms while simultaneously inducing therapeutic gene expression changes that address the underlying disease mechanism and prevent complications
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The marine invertebrate extract effectively activates genes like COL7A1 and downregulates MMP-3, promoting improved skin structure and reducing blister formation, offering a safer and more effective treatment for EB.
Implementation Method 1
heating marine invertebrate soluble collagen between 40°C - 100°C for between 10 minutes to 120 minutes, preferably between 60°C - 80°C for 45 minutes to 90 minutes, so as to hydrolyse the material
Implementation Method 2
heating marine invertebrate soluble collagen between 40°C - 100°C for between 10 minutes to 120 minutes, preferably between 60°C - 80°C for 45 minutes to 90 minutes, so as to hydrolyse the material
Data Source
Figure 1A~1E
Figure 2A~2E
Figure 3A~3E
AI summary
The present invention relates to a collagenous marine invertebrate extract for use in the treatment of Epidermolysis Bullosa, pharmaceutical compositions comprising said collagenous marine invertebrate extract, and methods for manufacturing the collagenous marine invertebrate extract of the invention.