Mass Analysis Device Peak Detection via Total Ion Chromatogram Alignment
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Atmospheric pressure ionization mass analysis devices face challenges in accurately computing the content of specific components in blood due to contamination and the need for precise analytical parameters, leading to potential misdiagnosis in screening tests.
Innovation Solution
The implementation of a mass analysis device with an ionization chamber using the flow injection method, a mass analysis unit, and a control unit that generates mass and total ion chromatograms, allowing for peak detection and alignment, and includes a comparison unit to correct and display chromatograms for accurate analysis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If flow injection method is used for sample introduction, then analysis time is reduced and productivity is improved, but measurement precision deteriorates due to contamination and difficulty in setting analytical parameters
Solution Approach 1:
The system performs preliminary actions by automatically setting analytical parameters and performing baseline corrections before actual measurement. The control unit pre-configures optimal parameters based on sample type and performs background subtraction to eliminate contamination effects, ensuring accurate measurements while maintaining high throughput from the flow injection method.
Solution Approach 2:
The system implements feedback mechanisms by continuously monitoring ion signal intensity and automatically adjusting analytical parameters. The control unit uses real-time feedback from the mass analyzer to optimize detection sensitivity and compensate for contamination effects, thereby maintaining measurement precision despite the rapid analysis speed of the flow injection method.
2Ease of operation
If atmospheric pressure ionization is used, then ease of operation is improved by eliminating complex separation steps, but reliability deteriorates due to device contamination
Solution Approach 1:
The system extracts and removes the harmful factor of contamination by implementing automatic baseline correction and background subtraction algorithms. The control unit separates the actual analyte signal from the contamination background, thereby maintaining reliable and consistent analysis results despite the inherent contamination risk in atmospheric pressure ionization systems.
Solution Approach 2:
The system changes operational parameters dynamically by automatically adjusting ionization voltage, gas flow rates, and mass analysis parameters based on sample characteristics. This adaptive parameter optimization ensures consistent and reliable analysis results while maintaining the operational simplicity of atmospheric pressure ionization without requiring complex separation steps.
3Quantity of substance
If multiple samples are analyzed sequentially for screening tests, then quantity of analysis is increased, but loss of time occurs due to device contamination requiring maintenance
Solution Approach 1:
The system maintains continuous useful action by implementing automatic contamination removal protocols and baseline corrections between samples. The control unit performs rapid background subtraction and parameter re-optimization without requiring physical device maintenance, enabling continuous analysis of large numbers of samples with minimal interruption and time loss.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables reliable detection of peaks in mass chromatograms even with low ion content, ensuring accurate computation of blood component content and facilitating differential diagnosis by aligning and comparing chromatograms.
Implementation Method 1
an ionization chamber 11, a first intermediate chamber 12 adjacent to the ionization chamber 11... In MS 10, an ionization chamber 11... a wire (not illustrated) is connected to the tip of the nozzle 152 so as to apply a high voltage of several kV from a voltage source (not illustrated), whereby ionization is performed
Implementation Method 2
the sample solution is sprayed out from the inside of round pipe 159. Furthermore, nitrogen gas is sprayed out from the space between round pipe 159 and round tubular nozzle 152. This arrangement causes the sprayed out sample solution to be atomized in the form of a mist due to the effect of collision with the nitrogen gas sprayed out around the round pipe 159
Implementation Method 3
ions which have been fed into the mass analysis chamber 14 are subjected to elimination of unneeded ions by means of the quadrupole inside the first mass analysis unit 16... only ions of a specified mass m/charge z which have reached the detector 18 are detected
Data Source
AI summary
A mass analysis device capable of reliably detecting the peak in a mass chromatogram of a given m/z is equipped with a control unit, which generates a mass chromatogram and total ion chromatogram. The control unit includes a determination unit which, using the total ion chromatogram, determines the start time and end time of the peak in the total ion chromatogram by searching for the peak based on maximum value of detected intensity and searching for peak start time and end time based on slope of change of detected intensity; and a detection unit, which detects the peak in the mass chromatogram by making the start time and end time of the peak in the mass chromatogram the same as the start time and end time of the peak in the total ion chromatogram.