Mass Analysis Data Verification Using Machine-State Trust Records

The patent implements feedback mechanisms by sequencing control samples (positive and negative) throughout the genomic analysis workflow. The results from these control samples are compared against expected outcomes, and any deviations trigger alerts or workflow adjustments. This closed-loop feedback system ensures data reliability without requiring complete redesign of the entire system architecture.

The patent applies preliminary action by preparing and sequencing control samples concurrently with patient samples at the beginning of each batching cycle. This advance preparation of control data establishes a baseline for quality assessment before the main analysis begins, enabling proactive quality assurance rather than reactive correction.

The patent merges the sequencing of control samples with the sequencing of patient samples by processing them in the same batching cycles using identical infrastructure. Multiple control samples are multiplexed together with patient samples in pooled libraries, allowing simultaneous sequencing without requiring separate dedicated time slots or additional sequencing capacity.

The patent maintains continuity of useful action by integrating control sample sequencing into the continuous patient sample processing workflow. Rather than pausing patient sample analysis to separately process controls, the system continuously sequences both types of samples in parallel batches, ensuring that quality monitoring occurs without interrupting the primary diagnostic function.