Mass Spectrometer Ion Screening With Fast Deflection Pulse Switching

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Solution Overview

Problem

Conventional mass spectrometers face issues with the service life of ion detectors due to the detection of non-target ions, which also interfere with the detection of target ions, and high-voltage pulse signals suffer from significant delays in switching, limiting their precision and application.

Innovation Solution

A method and system for selecting ions in a mass spectrometer using a deflection conductor with a high-voltage pulse circuit that applies different voltages to deflect non-target ions and allow target ions to reach the detector, and an RC series circuit to reduce switching delays in high-voltage pulse signals.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If all ions generated by exciting the sample are allowed to reach the ion detector, then the detector receives complete ion information, but the service life of the detector is shortened due to excessive non-target ions

Engineering Contradiction:
Improveservice life of detectorVSAvoidquantity of non-target ions
Core Design Contradiction:
ReliabilityVSQuantity of substance

Solution Approach 1:

The patent applies a first voltage to the deflection conductor before the ions reach the detector to generate a deflection electric field that redirects non-target ions away from the detector. This preliminary action prevents non-target ions from reaching the detector, thereby extending its service life while allowing target ions to be detected.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent dynamically switches the voltage applied to the deflection conductor between a first voltage (to deflect non-target ions) and a second voltage (to allow target ions through). This dynamic control enables selective ion detection based on arrival time, resolving the contradiction between detector protection and complete ion detection.

Inventive Principle:
Principle #15Dynamics

2Force

If high-voltage pulse signals are used for controlling ion deflection, then strong deflection effect is achieved, but significant delay occurs during voltage switching which limits control precision

Engineering Contradiction:
Improvedeflection electric field strengthVSAvoidvoltage switching delay
Core Design Contradiction:
ForceVSLoss of time

Solution Approach 1:

The patent uses periodic switching between first and second voltages on the deflection conductor, synchronized with the ion arrival patterns. This periodic action allows the system to achieve strong deflection when needed while accepting that switching delays occur at predictable intervals, maintaining control precision for ion selection.

Inventive Principle:
Principle #19Periodic action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach effectively prolongs the service life of the detector by minimizing non-target ion detection and enhances the precision of high-voltage pulse control, enabling more accurate ion selection and analysis.

Implementation Method 1

applying a first voltage to the deflection conductor to generate a deflection electric field at the deflection conductor

Methodology Applied
Scientific EffectElectric field: Electric Field

Implementation Method 2

ions are deflected to a trajectory not reaching the detector when flying through the deflection electric field

Methodology Applied
Scientific EffectIon deflection: Lorentz Force

Data Source

PatentUS20240371620A1Ion screening method and system for mass spectrometer, high-voltage pulse circuit, and selection circuit
Publication Date: 2024.11.07 AUTOBIO LABTEC INSTR CO LTD
  • US20240371620A1 patent drawing
  • US20240371620A1 patent drawing
  • US20240371620A1 patent drawing

AI summary

A method and a system for selecting ions in a mass spectrometer. The method comprises: applying a first voltage to a deflection conductor to generate a deflection electric field at the deflection conductor, where ions are deflected to a trajectory not reaching the detector when flying through the deflection electric field; maintaining the first voltage applied to the deflection conductor to deflect non-target ions which fly out of the acceleration electric field, in response to detecting that a pulse synchronized with a laser is outputted; applying a second voltage to the deflection conductor to stop generating the deflection electric field and enable target ions to reach the detector, in response to the target ions flying out of the acceleration electric field; and applying the first voltage to the deflection conductor, in response to all target ions flying past the deflection conductor.