Mastic Gum Solubilization via Ethanol Mediator

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Current methods for solubilizing mastic gum, a water-insoluble natural antibiotic, often require organic solvents like ethanol, which are undesirable in the cosmetics and health food industries, and result in limited solubility and stability issues.

Innovation Solution

A method involving dissolving mastic gum in ethanol, mixing with a polyol solution, cooling, filtering, and removing alcohol to produce a high-concentration aqueous mastic gum solution without organic solvents, using glycerin as a polyol and L-Ascorbic acid as a pH adjuster to enhance solubility and stability.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If mastic gum is dissolved in ethanol to achieve high solubility, then solubility is improved, but the presence of organic solvent becomes harmful for cosmetic and health food applications

Engineering Contradiction:

Improvesolubility of mastic gumVSAvoidpresence of organic solvent

Core Design Contradiction:

Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

The patent uses ethanol as an intermediary solvent to dissolve mastic gum, then removes it through distillation. The ethanol serves as a temporary mediator that enables high-concentration dissolution during processing but is eliminated before final product formation, thus achieving both high solubility and absence of harmful organic solvents in the final product.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent performs dissolution in ethanol as a preliminary step before final product formation. By conducting the dissolution process in advance and then removing the ethanol through distillation, the method prepares a high-concentration mastic gum solution that can be subsequently used without containing harmful organic solvents.

Inventive Principle:

Principle #10Preliminary action

2Quantity of substance

If conventional solubilization methods are used to achieve high concentration of mastic gum solution, then solubility is improved, but stability issues arise

Engineering Contradiction:

Improveconcentration of mastic gum solutionVSAvoidstability of mastic gum solution

Core Design Contradiction:

Quantity of substanceVSStability of the object's composition

Solution Approach 1:

The patent controls the concentration of mastic gum in the aqueous solution within a specific range (5-50 wt%) to optimize both solubility and stability. By adjusting this critical parameter, the method achieves high concentration while preventing precipitation and maintaining solution stability over time.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This method effectively produces a stable, high-concentration aqueous mastic gum solution that is suitable for various industrial applications, avoiding the use of organic solvents and improving solubility and stability.

Implementation Method 1

dissolving mastic gum in ethanol to prepare a first solution

Methodology Applied

Scientific EffectDissolution: Solvation

Implementation Method 2

cooling the third solution and filtering out an insoluble polymer resin from the third solution

Methodology Applied

Scientific EffectCooling-induced precipitation: Precipitation

Implementation Method 3

removing alcohol from the filtered third solution

Methodology Applied

Scientific EffectEvaporation: Evaporation

Implementation Method 4

removing alcohol from the filtered third solution

Methodology Applied

Scientific EffectDistillation: Distillation

Data Source

PatentUS10881127B1Manufacturing method of water-solubilized solution of mastic resin

Publication Date: 2021.01.05 VENN SKINCARE INC

AI summary

The present invention relates to a method of manufacturing a water-solubilized solution of mastic gum using a novel solvent system. The water-solubilized solution contains no organic solvent such as ethanol. With the new solvent system, a water-solubilized solution of mastic gum can be prepared with no organic solvents such as ethanol, but with a high amount of mastic gum dissolved therein.