Synergistic Microbicidal Composition Using MBIT and BIT Ratios

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Solution Overview

Problem

Commercial microbicides often fail to effectively control microorganisms, especially resistant strains and in aggressive environmental conditions, necessitating the development of synergistic combinations for enhanced activity while reducing individual microbicide levels for environmental and economic benefits.

Innovation Solution

A microbicidal composition comprising N-methyl-1,2-benzisothiazolin-3-one and sodium hydroxymethylglycinate in a weight ratio of 1:0.29 to 1:2.3, which provides enhanced efficacy at lower combined active ingredient levels, and can be formulated with solvents and carriers for various industrial applications.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If higher concentrations of individual microbicides are used, then microorganism control effectiveness is improved, but environmental harm and cost increase

Engineering Contradiction:
Improvemicroorganism control effectivenessVSAvoidenvironmental harm
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent combines two different microbicides (MBIT and BIT) in a synergistic formulation where the combination achieves superior microorganism control at lower total concentrations than either microbicide alone, thereby reducing environmental harm while maintaining effectiveness

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The invention creates a composite microbicidal system using specific weight ratios of MBIT and BIT (from 1:4 to 4:1) that produces a synergistic effect greater than the sum of individual components, allowing reduced dosing while achieving reliable microorganism control

Inventive Principle:
Principle #40Composite materials

2Reliability

If higher concentrations of individual microbicides are used, then microorganism control effectiveness is improved, but cost increases

Engineering Contradiction:
Improvemicroorganism control effectivenessVSAvoidcost
Core Design Contradiction:
ReliabilityVSQuantity of substance

Solution Approach 1:

By merging MBIT and BIT in optimized ratios, the formulation achieves enhanced microbicidal activity that allows lower total active ingredient dosing, reducing material costs while maintaining or improving control effectiveness

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The patent optimizes the concentration ratio parameters of MBIT and BIT to achieve synergistic effects, where the combined activity exceeds additive expectations, enabling cost-effective microorganism control at reduced dosing levels

Inventive Principle:
Principle #35Parameter changes

3Device complexity

If single microbicides are used, then formulation simplicity is maintained, but activity against resistant microorganisms is insufficient

Engineering Contradiction:
Improveformulation simplicityVSAvoidactivity against resistant microorganisms
Core Design Contradiction:
Device complexityVSReliability

Solution Approach 1:

The patent merges two microbicides with different modes of action to create a formulation that effectively targets resistant microorganisms while maintaining relative formulation simplicity and ease of use

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The combined MBIT-BIT formulation provides multi-functional microbicidal activity that addresses multiple types of microorganisms including resistant strains, making the single formulation universally effective across diverse microbial challenges

Inventive Principle:
Principle #6Universality (Multi-functionality)

Data Source

PatentEP2119355B1Microbicidal composition comprising N-methyl-1,2-benzisothiazolin-3-one
Publication Date: 2015.12.16 ROHM & HAAS CO
  • EP2119355B1 patent drawing

AI summary

Synergistic microbicidal compositions comprising N-methyl-1,2-benzisothiazolin-3-one.