Meal-Based Mulberry Composition for Postprandial Glucose Control

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Solution Overview

Problem

Current treatments for managing postprandial glucose response in diabetic and prediabetic individuals are limited, with existing drugs causing gastrointestinal side effects, and there is a need for alternative nutritional solutions that effectively reduce postprandial glucose and insulin spikes without capsules or pills.

Innovation Solution

A composition comprising mulberry leaf extract, a source of fiber, and unsaturated fatty acids administered with a meal to decrease postprandial glucose response.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional medications are used to manage postprandial glucose response, then glucose control effectiveness is improved, but gastrointestinal side effects increase

Engineering Contradiction:

Improveglucose control effectivenessVSAvoidgastrointestinal side effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent replaces traditional medications with a food-based composition that is consumed as part of the meal itself. The composition uses readily available food components (fiber, unsaturated fatty acids, amino acids) that provide glucose control benefits without the harmful side effects of pharmaceutical interventions. This approach substitutes short-term medication use with a sustainable dietary solution.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent introduces a food-based composition as an intermediary between the meal and the body's glucose metabolism. This composition acts as a mediator that modulates postprandial glucose response through its components (fiber, unsaturated fatty acids, amino acids), providing the benefits of glucose control while avoiding the direct harmful effects of medications on the gastrointestinal system.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If capsules or pills are used for treatment, then glucose control is achieved, but consumer acceptance and ease of use deteriorate

Engineering Contradiction:

Improveglucose controlVSAvoidconsumer acceptance

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent merges the treatment function with the meal itself by incorporating the therapeutic composition directly into food. Instead of requiring separate capsule or pill administration, the glucose-controlting components are integrated into the meal matrix, making the treatment indistinguishable from normal eating and significantly improving consumer acceptance and ease of use.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The patent creates a composition that serves multiple functions simultaneously: it provides nutritional value as part of the meal, delivers therapeutic benefits for glucose control, and improves consumer acceptance by being food-based rather than pharmaceutical. This multi-functionality eliminates the need for separate medication administration.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition significantly decreases postprandial glucose and insulin levels, improving glycemic control, managing weight, and reducing cardiovascular risk, while being more consumer-friendly than traditional medications.

Implementation Method 1

Mulberry leaves have been used centuries in traditional Chinese medicine as a common agent to treat a variety of conditions including diabetes... Research has shown that mulberry plant materials comprise various physiologically active components including flavonoids, polyphenols, polysaccharides, 1-deoxynojirimycin (DNJ) identified as α-glucosidase inhibitor

Methodology Applied

Scientific EffectAlpha-glucosidase inhibition: Enzyme

Implementation Method 2

The composition comprises a mulberry leaf extract, a source of fiber and a source of unsaturated fatty acids

Methodology Applied

Scientific EffectFiber absorption: Absorption (physical)

Implementation Method 3

The composition comprises a mulberry leaf extract, a source of fiber and a source of unsaturated fatty acids

Methodology Applied

Scientific EffectFat absorption: Absorption (physical)

Implementation Method 4

PPG are determined by several factors, such as the total caloric value of a meal, macronutrient composition, and carbohydrate quality... These include gastric emptying rate, intestinal absorption rate

Methodology Applied

Scientific EffectGastric emptying delay:

Data Source

PatentUS20250213635A1Use of a composition for managing postprandial glucose response and associated disorders

Publication Date: 2025.07.03 SOCIETE DES PRODUITS NESTLE SA

AI summary

The present invention generally relates to the use of a composition comprising mulberry leaf extract, a source of fiber and a source of unsaturated fatty acids to decrease postprandial glucose (PPG) response. More particularly, it relates to the use of such composition, administered with a meal, to decrease postprandial glucose (PPG) response. The invention also relates to a composition comprising a mulberry leaf extract, a source of fiber and a source of unsaturated fatty acids, administered with a meal, for use in the treatment and/or prevention of a disorder linked to postprandial glucose and/or postprandial insulin in a subject.