Meat-Derived Peptide Combinations for Satiety Signaling

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Solution Overview

Problem

Current understanding of obesity regulation is poorly understood, and existing solutions fail to effectively induce satiety and manage metabolic syndrome conditions like obesity, cardiovascular diseases, atherosclerosis, hypertension, hepatosteatosis, and diabetes.

Innovation Solution

Development of specific combinations of novel meat-derived polypeptides, such as the octapeptide ASDKPYIL and its variants, which are resistant to pepsin degradation and act as GLP-1 receptor agonists to induce satiation and satiety by signaling in intestinal cells, potentially used in conjunction with GLP-1 analogues for enhanced efficacy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional protein sources are used to induce satiety, then energy content is provided, but satiating effect is insufficient compared to the energy provided

Engineering Contradiction:

Improvesatiating effectVSAvoidenergy content

Core Design Contradiction:

ReliabilityVSUse of energy by moving object

Solution Approach 1:

The patent segments protein into specific peptides (5-50 amino acids) that are released through controlled proteolytic digestion. These segmented peptide units specifically target GLP-1 receptors to induce satiety, separating the satiating function from the general energy provision of complete proteins.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The patent changes the molecular parameter of protein by identifying and isolating specific peptide sequences (5-50 amino acids) that have optimized satiety-inducing properties. This parameter change allows the peptides to effectively bind GLP-1 receptors, enhancing the satiating effect per unit of energy.

Inventive Principle:

Principle #35Parameter changes

2Speed

If proteolytic digestion is accelerated to release satiety signals, then satiation is induced faster, but prolonged release and sustained satiety are reduced

Engineering Contradiction:

Improverate of digestionVSAvoidsatiety duration

Core Design Contradiction:

SpeedVSDuration of action of moving object

Solution Approach 1:

The patent employs periodic action through the coordinated release of multiple peptides with different digestion rates. Some peptides are released quickly for rapid satiation, while others provide sustained release for prolonged satiety, creating a periodic pattern of GLP-1 receptor stimulation that maintains satiety over time.

Inventive Principle:

Principle #19Periodic action

Solution Approach 2:

The patent ensures continuity of useful action by designing a mixture of peptides that maintain continuous GLP-1 receptor stimulation. The combination of fast- and slow-digesting peptides creates an uninterrupted satiety signal, preventing the breakdown in satiety that would occur with single-rate digestion.

Inventive Principle:

Principle #20Continuity of useful action

3Reliability

If specific peptide combinations are used to enhance satiety signaling, then satiation and satiety effects are improved, but complexity of the peptide combination increases

Engineering Contradiction:

Improvesatiety signaling efficacyVSAvoidpeptide combination complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies universality by using multiple peptides that all target the same GLP-1 receptor pathway. While the peptide sequences differ to provide varied digestion rates, they share the universal function of activating GLP-1 receptors, simplifying the mechanistic understanding despite the diversity of peptide components.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

These polypeptide combinations effectively reduce food intake, delay gastric emptying, and provide a synergistic effect with GLP-1 analogues, potentially leading to improved weight management and reduced incidence of metabolic syndrome-related conditions.

Implementation Method 1

dietary proteolytic products (peptides and amino acids) induce signalling in enteroendocrine cells of the intestine, which leads to secretion of various gut hormones

Methodology Applied

Scientific EffectCell signaling:

Implementation Method 2

which are readily taken up by the enterocytes and metabolized and/or transported into systemic circulation

Methodology Applied

Scientific EffectAbsorption: Absorption (physical)

Implementation Method 3

act as GLP-1 receptor agonists to induce satiation and satiety by signaling in intestinal cells

Methodology Applied

Scientific EffectGLP-1 receptor agonism:

Data Source

PatentUS20220315632A1Combination of dietary peptides

Publication Date: 2022.10.06 DIET4LIFE APS

AI summary

The present invention relates to the combination of dietary peptides, composition comprising such combinations including nutritional supplements and methods for inducing satiation and satiety, for preventing or reducing the incidence of metabolic syndrome comprising overweight and obesity, cardiovascular diseases, atherosclerosis, hypertension, hepatosteatosis, diabetes and/or cancer.