Mechanical Pressing Device for Fat-Depleted Adipose Tissue

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Solution Overview

Problem

Current methods for isolating adipose-derived mesenchymal stem cells for tissue regeneration are cumbersome, expensive, and time-consuming, often involving enzymes that can cause cell death and contamination, and require complex equipment and procedures.

Innovation Solution

A device and method for mechanically removing the fat phase from adipose tissue using pressing elements to produce a fat-depleted adipose tissue preparation, which can be enhanced with growth factors for stem cell proliferation and differentiation, and potentially mixed with bone tissue or substitutes for bone regeneration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If current methods for isolating adipose-derived mesenchymal stem cells are used, then stem cells can be obtained for tissue regeneration, but the process is cumbersome, expensive, and time-consuming

Engineering Contradiction:

Improvestem cell isolation effectivenessVSAvoidisolation process complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent extracts and removes the fat phase from adipose tissue through mechanical pressing, separating it from the adipose-derived mesenchymal stem cells. This extraction approach simplifies the isolation process by eliminating the need for complex enzymatic digestion and purification steps, directly addressing the contradiction between effective stem cell isolation and process complexity

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The patent replaces complex biochemical methods (enzymatic digestion, centrifugation, filtration) with a simple mechanical pressing system. The pressing device applies mechanical force to remove fat while preserving stem cells, substituting cumbersome laboratory procedures with a straightforward mechanical operation that reduces both device complexity and processing time

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

2Reliability

If enzymes are used to isolate stem cells from adipose tissue, then cell separation can be achieved, but cell death and contamination occur

Engineering Contradiction:

Improvecell separation effectivenessVSAvoidcell death and contamination

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent replaces enzymatic digestion with mechanical pressing to separate fat from stem cells. This mechanical approach avoids the harmful effects of enzymes (cell death and contamination) while achieving effective separation through physical force applied by the pressing device, directly resolving the contradiction between separation effectiveness and cell viability

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The pressing device enables the adipose tissue to self-separate into fat phase and stem cell phase through applied mechanical pressure. The tissue's natural structure allows fat to be mechanically expressed without external biochemical agents, eliminating enzyme-related harm while maintaining separation effectiveness

Inventive Principle:

Principle #25Self-service

3Reliability

If complex equipment and procedures are used for stem cell isolation, then isolation can be performed, but costs and time increase

Engineering Contradiction:

Improveisolation capabilityVSAvoidpreparation time

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The patent extracts the essential function of stem cell isolation from complex equipment and procedures, achieving it through a simple pressing operation. By removing fat mechanically rather than using multi-step biochemical protocols, the device dramatically reduces preparation time and cost while maintaining isolation capability

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The pressing device represents a simple, inexpensive, single-use or limited-use tool that replaces expensive, complex, and time-consuming laboratory equipment. The mechanical pressing system can be easily constructed and operated without requiring sophisticated instrumentation, directly addressing the contradiction between isolation capability and time/cost efficiency

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach simplifies and accelerates the preparation of adipose-derived stem cell-rich tissue for transplantation or injection, reducing costs and time, while improving the efficiency and success rate of tissue regeneration procedures.

Implementation Method 1

A device and method for mechanically removing the fat phase from adipose tissue using pressing elements

Methodology Applied

Scientific EffectMechanical compression: Compression

Data Source

PatentUS11813293B2Fat-depleted adipose tissue and a device and method for preparing the same

Publication Date: 2023.11.14 GENDLER 50 OWNERSHIP ZOHAR

AI summary

A device configured to mechanically remove a fat phase from at least one adipose tissue includes a first pressing element and a second pressing element. Furthermore, a method for preparing a preparation including a fat-depleted adipose tissue, comprises mechanically removing a fat phase from at least one adipose tissue. In addition, there is provided a preparation including a fat-depleted adipose tissue, wherein the fat-depleted adipose tissue is prepared by mechanically removing a fat phase from at least one adipose tissue.