Nasal Drug Delivery Device With Mechanical Stop for Equal Nostril Dosing

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Solution Overview

Problem

Existing intranasal drug delivery devices require complex operational steps for self-administration and often result in unequal drug distribution between nostrils due to the nasal cycle, leading to potential under-dosing.

Innovation Solution

A drug delivery device with a mechanical stop mechanism that allows for two-stage dose delivery, ensuring equal distribution of medication to each nostril by mechanically pausing between doses, facilitating self-administration with simplified operational steps.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Device complexity

If a single-stage drug delivery system is used, then the device complexity is reduced, but the dosing precision and equality between nostrils deteriorates

Engineering Contradiction:

Improvedevice complexityVSAvoiddosing precision

Core Design Contradiction:

Device complexityVSManufacturing precision

Solution Approach 1:

The drug delivery device is segmented into two distinct stages: a first stage for delivering a first dose to a first nostril, and a second stage for delivering a second dose to a second nostril. The mechanical stop divides the continuous delivery process into discrete segments, ensuring controlled and equal dosing to each nostril while maintaining relatively simple device structure.

Inventive Principle:

Principle #1Segmentation

2Manufacturing precision

If complex operational steps are required for self-administration, then the dosing precision can be improved, but the ease of operation deteriorates

Engineering Contradiction:

Improvedosing precisionVSAvoidease of operation

Core Design Contradiction:

Manufacturing precisionVSEase of operation

Solution Approach 1:

The device is designed for self-service intranasal administration without requiring complex operational steps. The mechanical stop automatically controls the delivery sequence, and the device can be easily held and activated by the user themselves, combining simple operation with precise dosing control.

Inventive Principle:

Principle #25Self-service

3Productivity

If no mechanical pause is provided between doses, then the productivity is improved, but the dosing equality between nostrils deteriorates

Engineering Contradiction:

ImproveproductivityVSAvoiddosing equality

Core Design Contradiction:

ProductivityVSManufacturing precision

Solution Approach 1:

The mechanical stop is pre-configured to automatically pause the drug delivery mechanism between the first and second stages. This preliminary built-in pause ensures that the user can properly transition between nostrils and receive equal dosing, while the device maintains efficient two-stage delivery capability.

Inventive Principle:

Principle #10Preliminary action

Data Source

PatentEP4208228B1Drug delivery devices with a mechanical stop

Publication Date: 2025.10.01 JANSSEN PHARMA NV

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AI summary

Various exemplary drug delivery devices with a mechanical stop, drug products utilizing the same, and methods of using drug delivery devices with a mechanical stop are provided. In general, a nasal drug delivery device is configured to dispense therefrom first and second doses of a drug therefrom into a nose. The drug delivery device includes a mechanical stop configured to provide a pause between the delivery of the first and second doses. During the pause, a user of the drug delivery device can move the drug delivery device from one nostril, into which the first dose was sprayed, to another nostril, into which the second dose can be sprayed. The mechanical stop is configured to hold the drug delivery device in a static delivery state.