Mectin Nanoparticle Formulations for Soil Mobility
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Solution Overview
Problem
Mectin and milbemycin insecticides face challenges due to rapid degradation, poor water solubility, and lack of systemic activity, leading to frequent applications and reduced efficacy in agricultural use.
Innovation Solution
Formulations of nanoparticles of polymer-associated mectin or milbemycin compounds with specific formulating agents, such as polyelectrolytes and dispersants, are developed to enhance stability, solubility, and mobility, allowing for improved application and pest control.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional mectin and milbemycin formulations are used, then pest control activity is achieved, but rapid degradation and photolysis reduce stability and duration of action
Solution Approach 1:
The patent segments the active ingredient into nanoparticle formulations (1-1000 nm), dividing the bulk chemical into controlled-release particles that degrade more slowly and provide sustained pest control activity over extended periods
Solution Approach 2:
The active ingredient is nested within polymer matrices and encapsulated in nanoparticle structures, providing protective layers that shield against photolysis and degradation while enabling controlled release over time
2Reliability
If traditional formulations are applied, then some pest control is achieved, but poor water solubility limits mobility and distribution in soil
Solution Approach 1:
The patent changes the physical parameters of the formulation by creating nanoparticles with specific size distributions (1-1000 nm) and using polymer associations that enhance water solubility while maintaining soil mobility and distribution capabilities
3Duration of action of stationary object
If macrocyclic lactones are taken up by plant leaves, then residual activity against mites is demonstrated, but lack of phloem and xylem mobility prevents true systemic effect
Solution Approach 1:
The patent transitions from foliar application with limited translocation to root-directed nanoparticle formulations that exploit the nanoparticle size advantage to achieve systemic movement through soil and plant uptake pathways, adding a new dimension of delivery
4Reliability
If frequent applications are made to compensate for rapid degradation, then pest control is maintained, but application frequency increases and efficiency decreases
Solution Approach 1:
The nanoparticle formulations provide continuous release of the active ingredient over extended periods, maintaining effective concentrations for pest control without requiring frequent reapplication, thus improving application efficiency
Data Source
AI summary
The present disclosure describes a formulation including a nanoparticle including a polymer-associated mectin and/or milbemycin compounds with an average diameter of between about 1 nm and about 500 nm; wherein the polymer is a polyelectrolyte, and a dispersant or a wetting agent. The disclosure describes various formulations and formulating agents that can be included in the formulations. Additionally, the disclosure describes application to various plants and pests as well as advantages of the disclosed formulations.