Medical Air Separator with Driven Actuator for Microbubble Removal

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Solution Overview

Problem

Existing air separators in extracorporeal blood treatment systems are ineffective in removing gas and air bubbles, particularly microbubbles, at higher blood flow rates due to insufficient residence time and centrifugal forces, leading to potential organ damage and cognitive impairments in hemodialysis patients.

Innovation Solution

A medical-technical air separator with a hollow-cylindrical air separation chamber designed for spiral blood flow, enhanced by a driven actuator that increases rotation, allowing for longer residence time and higher centripetal forces, effectively separating microbubbles across a wide range of blood flow rates.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If a conventional air separation chamber is used with lateral or tangential inflow to create vortex, then air bubbles can be separated at low flow rates, but at higher flow rates the residence time becomes insufficient and separation effectiveness decreases

Engineering Contradiction:
Improveair bubble separation effectivenessVSAvoidresidence time in chamber
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The patent applies the dynamics principle by introducing a driven actuator that actively rotates the air separation chamber. This dynamic rotation amplifies the vortex effect and centrifugal forces throughout the chamber, creating stronger separation forces that remain effective across a wide range of blood flow rates. The active rotation compensates for the reduced residence time at higher flow rates by intensifying the separation mechanism.

Inventive Principle:
Principle #15Dynamics

2Productivity

If blood flow rate is increased to improve treatment productivity, then more blood can be processed, but air bubble separation becomes insufficient due to shorter residence time

Engineering Contradiction:
Improveblood flow rateVSAvoidmicrobubble removal efficiency
Core Design Contradiction:
ProductivityVSReliability

Solution Approach 1:

The driven actuator dynamically rotates the chamber to maintain effective separation forces even at high blood flow rates. This active rotation ensures that centrifugal forces remain sufficient to separate microbubbles from blood regardless of the flow rate, allowing high productivity without sacrificing separation reliability.

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The patent changes the operational parameters by actively controlling the rotation speed of the chamber through the driven actuator. By adjusting the rotation speed, the system can optimize separation effectiveness for different blood flow rates, maintaining reliable microbubble removal whether the flow rate is high or low.

Inventive Principle:
Principle #35Parameter changes

3Device complexity

If the air separation chamber is designed without active rotation to simplify the device, then the device complexity is reduced, but separation effectiveness at higher flow rates becomes insufficient

Engineering Contradiction:
Improveair separator structureVSAvoidair separation performance
Core Design Contradiction:
Device complexityVSReliability

Solution Approach 1:

The patent replaces the passive mechanical design (relying solely on natural vortex from lateral inflow) with an active driven rotation system. The driven actuator provides controlled rotation that reliably generates the necessary centrifugal forces for effective separation, replacing insufficient natural convection with active mechanical rotation.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution achieves significantly improved separation of air or gas bubbles, especially microbubbles, ensuring reliable removal at both higher and lower blood flow rates, reducing the risk of organ damage and cognitive impairments.

Implementation Method 1

Due to the centrifugal or centripetal forces acting in this flow pattern, blood is forced radially outward, while air, and thus also air or gas bubbles, remain in the center of the rotating flow and the chamber

Methodology Applied
Scientific EffectCentrifugal force: Centrifugal Force

Implementation Method 2

the air separator has a driven actuator which is arranged and/or designed to amplify the rotation of the spiral blood flow... allowing for longer residence time and higher centripetal forces

Methodology Applied
Scientific EffectCentripetal force: Centrifugal Force

Data Source

PatentEP3326670B1Medical air separator for use in blood treatment
Publication Date: 2023.05.03 B BRAUN AVITUM
  • EP3326670B1 patent drawingFigure 1~2
  • EP3326670B1 patent drawingFigure 3~4
  • EP3326670B1 patent drawingFigure 5~7

AI summary

The invention relates to a medical air separator (1) for separating gas bubbles, in particular micro gas bubbles, from blood passed through the air separator (1), comprising a substantially hollow cylindrical air separation chamber (2) with a blood inlet (7) arranged longitudinally (6) on one side of the air separation chamber (2) and a blood outlet (8) formed longitudinally (6) on the other side, wherein the air separation chamber (2) is designed such that a blood flow (29) rotating substantially spirally about a longitudinal axis (29) of the chamber (2) can be formed from the blood inlet (7) to the blood outlet (8), wherein the air separator (1) has a driven actuator (11) for increasing the rotation of the spiral blood flow (29).It further relates to a blood tubing set and a device for extracorporeal blood treatment with such an air separator (1) and a method for separating gas bubbles from blood passed through the air separator (1).