Medical Implant Coating Adhesion via Binding Layer

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Solution Overview

Problem

Existing occluders face challenges with blood clotting, thrombosis, complex manufacturing processes, and short-term stability issues due to the use of artificial fibrous materials, which can lead to emboli and vascular occlusions, and require improved coatings for optimal blood flow restriction and long-term stability.

Innovation Solution

A method involving braiding or weaving strands to form a mesh with a first polymer coating providing binding force for a second coating, applied via spraying or electro-spinning, to enhance adhesion and restrict fluid flow, allowing for selective material distribution and optimized occluding properties.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If artificial fibrous material is used in an occluder to limit blood flow, then blood flow restriction is achieved, but blood clotting and thrombosis occur

Engineering Contradiction:
Improveblood flow restrictionVSAvoidblood clotting and thrombosis
Core Design Contradiction:
ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the material parameters from artificial fibrous material to biocompatible materials with specific surface properties that prevent thrombosis while maintaining blood flow restriction capability

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent uses composite material structures combining different biocompatible materials to achieve both blood flow restriction and thrombosis prevention functions simultaneously

Inventive Principle:
Principle #40Composite materials

2Reliability

If internal fabric or external membrane is added to occluder to limit blood flow, then occluding ability is improved, but manufacturing complexity and time increase

Engineering Contradiction:
Improveoccluding abilityVSAvoidmanufacturing complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent merges the blood flow restriction function directly into the occluder structure itself, eliminating the need for separate internal fabrics or external membranes

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The occluder structure is designed to perform multiple functions including blood flow restriction and structural support through its own configuration, without requiring additional specialized components

Inventive Principle:
Principle #6Universality (Multi-functionality)

3Object-affected harmful factors

If coating is applied to occluder surface to improve biocompatibility, then thrombosis risk is reduced, but coating adhesion and long-term stability are difficult to achieve

Engineering Contradiction:
Improvethrombosis riskVSAvoidcoating adhesion and stability
Core Design Contradiction:
Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent applies surface treatment or preliminary coating preparation steps that ensure strong adhesion before applying the biocompatible coating layer

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent uses an intermediary layer or surface treatment that mediates between the occluder material and the biocompatible coating, ensuring strong adhesion and long-term stability

Inventive Principle:
Principle #24Intermediary (Mediator)

4Manufacturing precision

If complex coating methods are used to achieve optimal blood flow restriction, then occluding precision is improved, but manufacturing time and complexity increase

Engineering Contradiction:
Improveoccluding precisionVSAvoidmanufacturing time
Core Design Contradiction:
Manufacturing precisionVSLoss of time

Solution Approach 1:

The patent segments the coating application into controlled zones or layers that can be applied efficiently while achieving precise blood flow restriction characteristics

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent optimizes coating parameters such as thickness, porosity, and material composition to achieve precise occluding function with simplified application processes

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The method improves the occluder's stability, reduces the risk of dislocation, and enhances biocompatibility and occluding ability by securely anchoring the coating, minimizing material interference and promoting long-term performance.

Implementation Method 1

said first coating provides a binding force to said second coating such that said second coating adheres to said strands

Methodology Applied
Scientific EffectAdhesion: Adhesive

Implementation Method 2

said second coating is applied by spraying, electro-spinning, electro-spraying or nano-spinning

Methodology Applied
Scientific EffectElectro-spinning: Electrohydrodynamics

Implementation Method 3

said second coating is applied by spraying, electro-spinning, electro-spraying or nano-spinning

Methodology Applied
Scientific EffectElectro-spraying: Electrohydrodynamics

Implementation Method 4

said second coating is applied by spraying, electro-spinning, electro-spraying or nano-spinning

Methodology Applied
Scientific EffectSpin coating: Spin Coating

Implementation Method 5

to enhance adhesion and restrict fluid flow

Methodology Applied
Scientific EffectFluid flow restriction:

Data Source

PatentEP3054854B1Method of producing a medical implant for occluding an opening in a body
Publication Date: 2019.08.07 OCCLUTECH HLDG AG
  • EP3054854B1 patent drawingFigure 1~2c
  • EP3054854B1 patent drawingFigure 3a~3c
  • EP3054854B1 patent drawingFigure 4a~4b

AI summary

The disclosure relates to a medical implant for occluding an opening in a body and a method of producing such a medical implant. Disclosed is an improved occluder, which provides improved occlusion, improved sealing and improved endothelialization. A method is disclosed comprising braiding, knitting or weaving together strands to form a body mesh of strands forming a plurality of adjacent cells delimited by the strands. The method further comprises applying a first coating to said strands, and applying a second coating to at least part of an external surface of said medical implant, wherein said first coating provides a binding force to said second coating such that said second coating adheres to said strands.