Medical Device Coating with Hydrophilic Anti-Bacterial Polymer
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Solution Overview
Problem
Existing methods for modifying medical device surfaces to enhance biocompatibility, hydrophilicity, and bacteria adhesion inhibiting capability are inadequate, often requiring additional sterilization steps and failing to provide sufficient hydrophilicity and bacteria adhesion inhibition.
Innovation Solution
A method involving a contacting step with a solution containing a hydrophilic polymer A, which includes a compound with a quaternary ammonium cation group and a specific structure, followed by a heating step at a pH of 6.1 to 8.0, forms a coating on the medical device surface, providing both hydrophilicity and bacteria adhesion inhibition.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a medical device is heated in a pH 2.0 to 6.0 solution containing a polymer having a hydroxyl group to form a coating, then good hydrophilicity is achieved, but additional sterilization is required and bacteria adhesion inhibition is insufficient
Solution Approach 1:
The patent changes the pH parameter to 6.1-8.0 (physiological range) and uses a polymer with specific functional groups (carboxyl, hydroxyl, amine) to achieve both hydrophilicity and bacteria adhesion inhibition in a single step, eliminating the need for additional sterilization processes
Solution Approach 2:
The coating polymer is designed to perform multiple functions simultaneously: providing hydrophilicity, preventing bacteria adhesion, and maintaining physiological compatibility, thereby replacing multiple separate treatment steps with a single universal coating process
2Reliability
If existing coating methods are used to enhance hydrophilicity, then some hydrophilicity is achieved, but sufficient hydrophilicity and bacteria adhesion inhibition cannot be obtained simultaneously
Solution Approach 1:
The patent employs a composite polymer coating containing multiple functional groups (carboxyl, hydroxyl, amine) that work synergistically to provide both hydrophilicity and bacteria adhesion inhibition, combining the benefits of different functional moieties in a single coating layer
Solution Approach 2:
The coating is designed with specific local chemical properties at the surface, including hydrophilic groups for water interaction and antibacterial functional groups for pathogen resistance, creating different local functions within the same coating layer
3Reliability
If a coating is formed using existing methods, then some surface modification is achieved, but the process requires additional sterilization steps
Solution Approach 1:
The patent combines the coating formation process with sterilization and biocompatibility enhancement into a single integrated operation, where the coating polymer itself provides the necessary biocompatible and antibacterial properties, eliminating the need for separate sterilization steps
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method results in a coated medical device with sufficient hydrophilicity and bacteria adhesion inhibiting capability, eliminating the need for additional sterilization steps and simplifying the manufacturing process.
Implementation Method 1
a contacting step of housing a medical device in a container, and bringing the medical device into contact with a solution a containing a hydrophilic polymer A
Implementation Method 2
a heating step of heating the container; wherein the hydrophilic polymer A is a polymer containing, as a monomer unit, a compound having a quaternary ammonium cation group
Data Source
AI summary
An object of the present invention is to provide a simple method for manufacturing a coated medical device allowed to have not only properties such as sufficient hydrophilicity but also a bacteria adhesion inhibiting capability. The present invention provides a method for manufacturing a coated medical device, including: (A) a contacting step of housing a medical device in a container, and bringing the medical device into contact with a solution a containing a hydrophilic polymer A; and (C) a heating step of heating the container; wherein the hydrophilic polymer A is a polymer containing, as a monomer unit, a compound having a quaternary ammonium cation group; and wherein the pH of the solution a after the heating step is 6.1 to 8.0.