Medical Device Coating Using Rotational Phase Change
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Solution Overview
Problem
Existing methods for coating implantable medical devices fail to effectively prevent thrombosis and platelet deposition on luminal and abluminal surfaces, leading to reduced patency rates and compromised device function in vascular applications.
Innovation Solution
A method involving the application of a thromboresistant polymer coating, such as polyurethane urea blended with a siloxane containing surface modifying additive, to the luminal and abluminal surfaces of medical devices, where the polymer is applied in liquid form and partially solidified while rotating, optionally with bioactive materials incorporated for enhanced thromboresistance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional coating methods are applied to medical devices, then the device structure is formed, but thrombosis and platelet deposition occur on the surfaces
Solution Approach 1:
The patent applies a multi-layer composite coating system consisting of an inner thromboresistant polymer layer (such as polyurethane urea with siloxane additives) and an outer protective layer. This composite structure combines the thromboresistant properties of the inner layer with the mechanical durability of the outer layer, effectively preventing thrombosis and platelet deposition while maintaining device patency.
Solution Approach 2:
The patent modifies the surface properties of the medical device by changing the chemical composition and physical parameters of the coating materials. Specifically, it uses polymers with controlled surface energy, hydrophilicity, and molecular weight to create a non-thrombogenic surface that resists platelet adhesion and maintains blood compatibility.
2Manufacturing precision
If the medical device is rotated during coating application, then uniform coating distribution is achieved, but the coating process complexity increases
Solution Approach 1:
The patent employs dynamic rotation of the medical device during the coating application process. The device is rotated at controlled speeds to ensure uniform distribution of the coating material across the luminal and abluminal surfaces. This dynamic approach allows the coating to be applied evenly while the device rotates, achieving consistent thickness and coverage.
Solution Approach 2:
The patent replaces complex multi-axis positioning systems with a simpler rotational mechanism. Instead of using sophisticated robotic arms or multi-degree-of-freedom positioning systems to achieve uniform coating, the invention uses a single rotational degree of freedom combined with linear coating material delivery, significantly simplifying the overall coating system while maintaining manufacturing precision.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution significantly reduces thrombosis and platelet deposition, thereby improving the patency and functionality of implantable medical devices by creating a biocompatible, non-thrombogenic surface that minimizes occlusion and enhances blood flow.
Implementation Method 1
applying a first polymer in liquid form to the luminal surface; and at least partially solidifying the first polymer while rotating
Implementation Method 2
rotating the medical device about the longitudinal axis; applying a first polymer in liquid form to the luminal surface; and at least partially solidifying the first polymer while rotating
Data Source
AI summary
Methods for coating medical devices for implantation within a body vessel are provided comprising providing a cylindrical container, placing a medical device inside the cylindrical container, and applying a polymer in liquid form inside the container.