Longitudinal Medical Image Alignment for Follow-Up Review

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Solution Overview

Problem

Existing medical imaging systems lack an automatic workflow for comparing follow-up images of the same patient acquired under different protocols and parameters, leading to difficulties in assessing physiological responses to treatments due to varying image characteristics.

Innovation Solution

A computing device automatically aligns image volumes from different time points using registration and transformation, generating aligned and difference images, and transfers them to a PACS for viewing, allowing radiologists to compare images under similar conditions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If manual comparison of follow-up images is performed, then radiologists can assess treatment responses, but the process is time-consuming and prone to errors due to varying image characteristics

Engineering Contradiction:
Improveaccuracy of treatment response assessmentVSAvoidtime required for longitudinal review
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent introduces an automated image registration system as an intermediary between the acquisition of follow-up images and the radiologist's assessment. This system automatically aligns images from different time points and imaging conditions, eliminating manual comparison efforts and providing precisely registered images for accurate treatment response evaluation.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent replaces the manual mechanical process of image comparison with an automated computational system. The automated registration algorithm processes images using computer-based image registration techniques, substituting the manual visual comparison process and thereby reducing time consumption while maintaining or improving assessment accuracy.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Adaptability or versatility

If follow-up scans are performed under different protocols and parameters, then imaging flexibility is improved, but image characteristics vary making comparison difficult

Engineering Contradiction:
Improveimaging protocol flexibilityVSAvoidconsistency of image characteristics for comparison
Core Design Contradiction:
Adaptability or versatilityVSMeasurement precision

Solution Approach 1:

The patent acknowledges that imaging parameters (such as contrast timing, slice thickness, and reconstruction settings) change between follow-up scans for clinical reasons. The automated registration system is designed to handle these parameter variations by using robust registration algorithms that can align images despite differences in acquisition protocols, thereby maintaining comparison consistency while preserving imaging flexibility.

Inventive Principle:
Principle #35Parameter changes

3Productivity

If automated image registration is implemented, then review time is reduced, but system complexity increases

Engineering Contradiction:
Improveefficiency of longitudinal reviewVSAvoidcomplexity of automated alignment system
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The automated registration system is designed to operate autonomously without requiring complex user intervention. The system automatically detects corresponding anatomical landmarks, computes transformation parameters, and generates aligned images independently. This self-service capability simplifies the user interface and reduces operational complexity while maintaining high productivity.

Inventive Principle:
Principle #25Self-service

Data Source

PatentUS12518869B2System and method for automated longitudinal review
Publication Date: 2026.01.06 GE PRECISION HEALTHCARE LLC
  • US12518869B2 patent drawing
  • US12518869B2 patent drawing
  • US12518869B2 patent drawing

AI summary

A computer-implemented method for automatically performing a longitudinal review of medical imaging data via one or more processors includes obtaining, at a computing device, a first image volume acquired of a subject with a medical imaging system of an imaging modality. The method also includes obtaining, at the computing device, a second image volume acquired of the subject with the medical imaging system or another medical imaging system of the imaging modality or a different imaging modality, wherein the first image volume was acquired at an earlier time point than the second image volume. The method further includes automatically aligning, via the computing device, the second image volume to the first image volume to generate aligned image volumes.