3D Medical Image Segmentation via Overlapping Sub-Image CNNs

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Solution Overview

Problem

Current medical image segmentation methods using neural networks are often non-specific to medical imaging and do not effectively leverage the structured and recurrent nature of anatomical features in medical images, leading to inefficiencies in identifying and segmenting anatomical structures.

Innovation Solution

The method involves dividing a 3D medical image into nine partially overlapping sub-images, each analyzed by a convolutional neural network (CNN), and combining their results to achieve a single segmentation of the initial image, utilizing a knowledge database to exploit the specific localization of organs and tissues.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If a single neural network analyzes the entire 3D medical image, then the segmentation process is simple, but the processing time is long and efficiency is low

Engineering Contradiction:
Improvesegmentation speedVSAvoidsystem architecture complexity
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The patent divides the 3D medical image into multiple 2D slices along the Z-axis, with each slice further divided into four quadrants. This segmentation allows parallel processing of multiple regions by different neural networks, significantly reducing processing time while maintaining segmentation accuracy through the structured division of the image into manageable portions.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent transforms the 3D image analysis problem into a series of 2D slice analyses. By processing each 2D slice independently and then combining the results, the system achieves efficient parallel processing while maintaining the 3D anatomical context. This dimensional transformation enables faster processing compared to analyzing the entire 3D volume with a single network.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

2Measurement precision

If standard neural network architecture is used, then the model is simple and easy to implement, but it lacks specificity to medical imaging content

Engineering Contradiction:
Improvesegmentation accuracyVSAvoidnetwork architecture complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent assigns different neural networks to different quadrants of each 2D slice, allowing each network to be specialized for specific anatomical regions. This local quality approach enables each network to develop region-specific features and patterns, improving segmentation accuracy for that particular anatomical area while maintaining overall system functionality.

Inventive Principle:
Principle #3Local quality

Solution Approach 2:

The patent creates a universal framework where multiple neural networks process different parts of the same image simultaneously. Each network follows the same basic architecture and training methodology but is applied to different spatial regions, achieving both specialization for specific anatomical structures and generalization through the unified processing framework.

Inventive Principle:
Principle #6Universality (Multi-functionality)

3Loss of time

If the image is divided into multiple sub-images for parallel processing, then processing time is reduced, but the complexity of combining results increases

Engineering Contradiction:
Improveprocessing timeVSAvoidresult integration complexity
Core Design Contradiction:
Loss of timeVSDevice complexity

Solution Approach 1:

The patent merges the segmentation results from multiple 2D slices and quadrants by combining the labeled pixel information across all sub-images. The merging process reconstructs the complete 3D segmentation by aggregating results from all processed regions, maintaining anatomical consistency through the structured combination approach that leverages the systematic division of the original image.

Inventive Principle:
Principle #5Merging (Combining)

Data Source

PatentEP3738100B1Automatic segmentation process of a 3D medical image by one or several neural networks through structured convolution according to the anatomic geometry of the 3D medical image
Publication Date: 2024.06.12 INST DE RECH SUR LES CANCERS DE LAPPAREIL DIGESTIF IRCAD
  • EP3738100B1 patent drawingFigure 1
  • EP3738100B1 patent drawingFigure 2~3B
  • EP3738100B1 patent drawingFigure 4~5

AI summary

This invention concerns an automatic segmentation method of a medical image making use of a knowledge database containing information about the anatomical and pathological structures or instruments, that can be seen in a 3D medical image of a x b x n dimension, i.e. composed of n different 2D images each of a x b dimension. Said method being characterised in that it mainly comprises three process steps, namely: a first step consisting in extracting from said medical image nine sub-images (1 to 9) of a/2 x b/2 x n dimensions, i.e. nine partially overlapping a/2 x b/2 sub-images from each 2D image; a second step consisting in nine convolutional neural networks (CNNs) analysing and segmenting each one of these nine sub-images (1 to 9) of each 2D image; a third step consisting in combining the results of the nine analyses and segmentations of the n different 2D images, and therefore of the nine segmented sub-images with a/2 x b/2 x n dimensions, into a single image with a x b x n dimension, corresponding to a single segmentation of the initial medical image.