Medical Image Processing for Tissue Marker Correlation
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Solution Overview
Problem
Molecular markers in tissue samples are not always expressed homogeneously, leading to potential false-positive or false-negative examination results in medical diagnostics, and existing methods struggle to accurately link medical image data with pathological molecular marker information for precise diagnosis.
Innovation Solution
A medical information processing system and apparatus that identifies tissue positions and obtains image feature values from medical image data, associating them with pathological examination results to generate relevance information for precise prediction of examination outcomes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If molecular marker examination is performed on tissue samples, then diagnostic information about disease prognosis and medicinal effects can be obtained, but false-positive or false-negative results may occur due to non-homogeneous expression of molecular markers in the tissue
Solution Approach 1:
The patent combines medical image data covering the entire lesion with molecular marker examination results from tissue samples. By merging these two types of data, the system creates a more comprehensive diagnostic tool that links the spatial distribution of molecular markers with the overall lesion characteristics, thereby improving diagnostic reliability and reducing false results.
Solution Approach 2:
The patent segments the lesion into multiple regions and performs molecular marker examinations on different segments. By dividing the lesion into multiple parts and examining each separately, the system captures the non-homogeneous expression of molecular markers across different regions, leading to more accurate overall diagnostic results.
2Measurement precision
If medical image data is linked with pathological molecular marker information, then diagnostic precision can be improved, but the complexity of the system increases
Solution Approach 1:
The patent introduces a medical information processing apparatus as an intermediary that automatically links medical image data with molecular marker examination results. This intermediary system manages the complexity of data integration, association, and analysis, thereby improving diagnostic precision without requiring direct manual coordination between different diagnostic modalities.
3Loss of information
If tissue samples are collected for molecular marker examination, then information about molecular marker expression can be obtained, but the samples may not represent the entire lesion due to non-homogeneous expression
Solution Approach 1:
The patent makes the medical image data serve multiple functions: it provides overall lesion visualization, enables localization of tissue samples within the lesion, and allows correlation with molecular marker results. By using the medical image data universally across these different diagnostic needs, the system compensates for the limited sampling of tissue and achieves more complete information about molecular marker expression throughout the entire lesion.
Data Source
AI summary
A medical information processing system according to an embodiment includes processing circuitry. The processing circuitry is configured to identify the position of a tissue from first medical image data represented by an image of a target site acquired before the tissue in the target site was collected and to obtain an image feature value of the tissue. The processing circuitry is configured to obtain an examination result of a pathological examination performed on the tissue. The processing circuitry is configured to bring the image feature value of the tissue into association with the examination result of the pathological examination.