Medicament Mixing With Temperature-Compensated Conductivity
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Solution Overview
Problem
Existing medicament preparation systems face challenges in ensuring uniform mixing and accurate concentration control, particularly in continuous fluid preparation, leading to potential variations and inefficiencies in medicament production.
Innovation Solution
A system and method involving concurrent mixing of water and concentrate in a mixing container, followed by temperature-compensated conductivity measurements and controlled dilution, ensures uniform mixing and precise concentration adjustment, using a controller to manage fluid flow and valves to achieve a ready-to-use medicament.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If continuous fluid preparation and proportioning is employed, then productivity is improved, but manufacturing precision deteriorates due to potential variations in medicament concentration
Solution Approach 1:
The system uses periodic reciprocating motion of the pump to create alternating filling and emptying phases in the mixing chamber, which enhances mixing efficiency while maintaining continuous operation. This periodic action ensures uniform concentration distribution without sacrificing preparation speed
Solution Approach 2:
The system incorporates sensors to monitor medicament concentration in real-time and provides feedback to the control unit, which adjusts pump parameters to maintain precise concentration control during continuous preparation operations
2Manufacturing precision
If batch medicament preparation is used, then manufacturing precision is improved, but productivity deteriorates due to longer preparation time
Solution Approach 1:
The system enables continuous preparation of medicament batches without interruption, where the mixing chamber continuously receives concentrate and diluent while being periodically agitated. This eliminates idle time between batches while maintaining precise concentration control through continuous monitoring and adjustment
3Productivity
If rapid mixing is implemented to reduce preparation time, then productivity is improved, but manufacturing precision deteriorates due to insufficient mixing uniformity
Solution Approach 1:
The pump operates in periodic reciprocating cycles, rapidly filling and emptying the mixing chamber multiple times. This periodic action creates intense mixing action that achieves uniform concentration distribution quickly, maintaining both high mixing speed and precise concentration uniformity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution ensures rapid and accurate mixing with reduced time and variation, achieving consistent medicament concentration within safe medical ranges, thereby improving the quality and reliability of medicament production.
Implementation Method 1
A peristaltic pump is known to be employed in dialysis and other medical applications
Implementation Method 2
Flow through the drain line 115 has a temperature sensor 120 and a conductivity sensor 131 to permit the acquisition by the controller 155 of a temperature-compensated conductivity measurement
Implementation Method 3
Flow through the drain line 115 has a temperature sensor 120 and a conductivity sensor 131 to permit the acquisition by the controller 155 of a temperature-compensated conductivity measurement
Implementation Method 4
A check valve 114 with a predefined cracking pressure creates a back pressure which is overcome by the peristaltic pump 110 and the water pump 129
Data Source
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AI summary
A system for mixing a batch of medicament has a pump actuator, control valve actuators, a source of concentrate, and a purified water source, all connected by a fluid circuit. A controller controls various control valves to open fluid channels from the source of concentrate and from the purified water source to connect a junction of the fluid circuit to the concentrate container and the purified water source. The controller also controls the pump actuator and a water pump to flow water and concentrate through the junction into a mixing container, such that the mixture of the concentrate and the water requires additional dilution to form a ready-to-use medicament. The controller samples the mixture and calculate an additional quantity of water to add based on the sampling.