Medicament Delivery Device Priming Mechanism
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Solution Overview
Problem
Conventional medicament delivery devices face challenges in efficiently removing entrapped air, leading to potential harm, dose accuracy issues, and psychological concerns for patients, particularly when using multi-chamber cartridges with powdered medicaments, which require priming with excess medicament to ensure air expulsion.
Innovation Solution
A medicament delivery device featuring a priming mechanism with fine pitch threads and a locking system that allows precise displacement of the medicament container, ensuring minimal medicament wastage and preventing unintended priming, utilizing a priming device with tune engagement means and a locking mechanism to prevent accidental displacement.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If priming is performed by expelling a small dose of medicament to remove entrapped air, then air is removed from the cartridge and needle, but medicament is wasted and dose accuracy is reduced
Solution Approach 1:
The device segments the priming function from the dosing function by providing a separate priming chamber that is distinct from the main medicament container. This allows air removal to occur in a dedicated space without compromising the integrity and quantity of the dosed medicament.
Solution Approach 2:
A separate priming chamber acts as an intermediary space between the medicament container and the needle. This intermediate chamber captures and holds the expelled air and priming fluid, preventing direct loss of medicament from the main container and allowing controlled disposal of the priming waste.
2Reliability
If a large dose is set to ensure all air has been expelled during priming, then air is completely removed, but unnecessary medicament is wasted
Solution Approach 1:
The device performs partial priming by providing a dedicated priming chamber that handles only the necessary amount of air removal. The priming chamber is sized to accommodate just enough volume for complete air expulsion without requiring excessive medicament disposal, thus achieving reliable air removal with minimal waste.
Solution Approach 2:
The priming chamber is pre-configured and separated from the main medicament container before dosing begins. This preliminary arrangement allows air removal to be completed in advance in a controlled environment, ensuring complete air expulsion while preserving the exact dosed amount in the main container.
3Ease of operation
If the needle is mounted on the cartridge for a longer period, then the patient can prepare, but air can be sucked into the cartridge due to atmospheric conditions changing
Solution Approach 1:
The device segments the sealed medicament container from the needle assembly by introducing a priming chamber as an intermediate component. This segmentation maintains the hermetic seal of the main container during needle mounting and patient preparation, while the priming chamber serves as a controlled interface that prevents atmospheric air from being drawn into the medicament supply.
4Object-affected harmful factors
If conventional priming mechanisms are used, then air can be expelled, but the device construction becomes unnecessarily complicated and linked to needleless injectors
Solution Approach 1:
The priming chamber is designed as a multi-functional component that serves both as a hermetic seal maintenance mechanism during needle attachment and as an air expulsion chamber during priming. This universal design eliminates the need for separate needleless injector mechanisms while achieving effective air removal, thereby reducing overall device complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables precise expulsion of air without wasting medicament, ensuring accurate dosing and preventing unintentional priming, thus enhancing safety and reliability in medicament delivery.
Implementation Method 1
the priming device (34) comprises a distal end comprising fine pitch threads (24) arranged to cooperate with corresponding fine pitch threads arranged at the proximal housing
Implementation Method 2
utilizing a priming device with tune engagement means and a locking mechanism to prevent accidental displacement
Implementation Method 3
a plunger rod having opposite proximal and distal ends and being arranged within said distal housing, wherein the proximal end of the plunger rod is abutting the stopper of the container; drive means arranged within said distal housing and being operably connected to said plunger rod for driving said plunger rod and thereby said stopper towards the proximal end of the device
Data Source
AI summary
A medicament delivery device includes distal and proximal housings; a medicament container having a slidable stopper partially, slidably arranged within the proximal housing; a plunger rod within the distal housing having a proximal end abutting the stopper; a driver within the distal housing operably connected to the plunger rod for driving the plunger rod and stopper toward the device's proximal end; and a priming device having a distal end including an engagement mechanism arranged to cooperate with an engagement mechanism at the housing's proximal end, an end wall abutting the container's proximal end, and a passage on the end wall. An engagement mechanism at the priming device's proximal end cooperates with a delivery member engagement mechanism. Distal displacement of the priming device relative to the proximal housing causes distal displacement of the container relative to the plunger rod, forcing proximal displacement of the stopper, thereby priming the container.