Medicated Module Premix Medicament Delivery
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Solution Overview
Problem
Current drug delivery systems face challenges in administering multiple medicaments simultaneously, as pre-mixed formulations have fixed ratios that cannot be adjusted, and users with dexterity or computational difficulties struggle to accurately calculate and deliver combined doses, leading to inefficiencies and potential incomplete medication delivery.
Innovation Solution
A medicated module with a premixed secondary medicament reservoir that, when attached to a primary drug delivery device, allows for a single dose setting to automatically determine the dose of both medicaments, ensuring accurate and variable delivery through a single dispense interface, such as a hollow needle cannula, with features like bypass channels for priming and safety seals to prevent mixing and ensure complete dose delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If pre-mixed formulations of multiple active agents are used, then combination therapy can be delivered simultaneously, but the fixed ratio of active components cannot be varied for different users or therapy stages
Solution Approach 1:
The system divides the drug delivery into separate modules: a primary reservoir containing a first active agent and a secondary reservoir containing a second active agent. Each reservoir can be independently configured with different volumes and concentrations, allowing flexible dose ratios while maintaining simultaneous delivery capability through the single dispense interface.
2Adaptability or versatility
If multiple separate drug delivery systems are used to deliver different medicaments, then dose flexibility can be maintained, but users with dexterity or computational difficulties struggle to accurately calculate and deliver combined doses
Solution Approach 1:
The system merges multiple drug delivery functions into a single integrated device with one dispense interface. The controller automatically calculates and coordinates the delivery of both active agents based on the dose setting, eliminating the need for users to perform separate calculations or operations for each medicament.
Solution Approach 2:
The controller performs automatic dose calculation and coordination of the two active agents based on user input. The system self-regulates the delivery timing and amounts of both drugs, freeing the user from computational tasks and ensuring accurate combined dosing without requiring manual calculation.
3Stability of the object's composition
If active components are stored separately and combined at the point of delivery, then stability and therapeutic performance are improved, but the process for combining the two agents needs to be simple and convenient for the user to perform reliably
Solution Approach 1:
The system pre-configures the separate reservoirs with the appropriate volumes and concentrations of active agents before use. The controller is pre-programmed with the relationship between the two agents, so that when the user activates the single dispense interface, the system automatically executes the correct combination timing and dosage without requiring manual mixing or calculation during administration.
Data Source
AI summary
A medicated module (4) for an injection system to co-deliver at least two medicaments (1, 2) is disclosed where a primary delivery device (7) contains a first drug agent and accepts a medicated module (4) containing a single dose of a secondary premix medicament (2) containing the first drug agent and at least a second drug agent, where both the primary medicament (1) and the secondary premix medicament (2) are delivered through a single hollow needle (3, 16, 21, 31).