Medicated Module for Variable Dose Drug Delivery
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Solution Overview
Problem
Current drug delivery systems face challenges in administering multiple medicaments simultaneously, as pre-mixed formulations have fixed ratios that cannot be adjusted, and users with dexterity or computational difficulties struggle to accurately calculate and deliver the correct dose combinations, especially when requiring variable proportions of active agents.
Innovation Solution
A drug delivery system with separate reservoirs for multiple drug agents, allowing a single dose setting to automatically determine the dose of one medicament and enabling variable dosing through a single dispense interface, such as a hollow needle cannula, where the secondary medicament is activated upon primary medicament dispensing, facilitating easy and accurate administration of complex drug combinations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If pre-mixed formulations of multiple active agents are used, then the therapeutic performance can be optimized with fixed ratios, but the dosing proportions cannot be adjusted for different users or treatment stages
Solution Approach 1:
The invention divides the medication system into separate reservoirs for each active agent, allowing independent storage and controlled combination at the time of administration. This segmentation enables both fixed-ratio pre-mixed formulations (when both reservoirs are connected) and flexible dosing (when reservoirs are used separately or in different configurations), resolving the contradiction between therapeutic optimization and dosing adaptability.
2Stability of the object's composition
If separate storage containers for multiple drug agents are used, then the stability and compatibility of agents are improved, but the device complexity and user operation difficulty increase
Solution Approach 1:
The invention merges multiple separate storage containers into a single integrated cartridge assembly that attaches to the injection device. This combining approach maintains the stability benefits of separate storage while reducing overall device complexity through unified housing, common sealing mechanisms, and simplified user interaction, effectively resolving the contradiction between agent stability and device complexity.
3Measurement precision
If users must calculate and set doses for multiple medicaments separately, then the dosing precision can be controlled, but the ease of operation decreases for users with dexterity or computational difficulties
Solution Approach 1:
The invention implements self-service dosing through automatic dose calculation and delivery mechanisms. The system automatically determines the required doses of multiple medicaments based on pre-programmed protocols or user inputs, eliminating the need for manual calculation and separate setting of each dose. This maintains dosing precision while dramatically improving ease of operation for users with dexterity or computational difficulties.
4Adaptability or versatility
If multiple drug delivery systems are used for combination therapy, then the versatility of treatment options is improved, but the loss of time and complexity of administration increase
Solution Approach 1:
The invention creates a universal drug delivery system capable of administering multiple different medicament combinations through a single device. The cartridge assembly can be configured with different reservoirs containing various active agents, allowing the same injection device to deliver different treatment regimens. This multi-functionality maintains treatment versatility while reducing administration time by consolidating multiple injections into a single delivery action.
Data Source
AI summary
A medicated module (4) for an injection system to co-deliver at least two medicaments (1, 2) is disclosed where a primary delivery device (7) containing a primary medicament (1) accepts a medicated module (4) containing a single dose of a secondary medicament (2) and where both medicaments (1, 2) are delivered through a single hollow needle (3, 16, 21, 31).