Medication Dose Adjustment Using Sparse Glucose-Dose Pairs

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Solution Overview

Problem

Diabetic patients often fail to adhere to regular blood glucose monitoring due to various limitations, leading to infrequent medication dose adjustments, which can impact the effectiveness of their treatment regimen.

Innovation Solution

A computing device-based method that allows for medicament dose adjustments using a relaxed dosing regimen, requiring a minimum number of dose and blood glucose measurement pairs within a defined time frame, enabling dose adjustments even with incomplete adherence to daily monitoring.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If a patient misses a scheduled medication dose, then the medication schedule becomes disrupted, but manually calculating and adjusting subsequent doses introduces complexity and potential for error

Engineering Contradiction:
Improvemedication dosing accuracyVSAvoiddose calculation complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The system automatically calculates and adjusts medication dosing schedules without requiring manual intervention. The processor self-services by receiving information about missed doses and autonomously determining adjusted dosing times and amounts, eliminating the need for healthcare providers or patients to perform complex manual calculations.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The system incorporates feedback mechanisms where information about actual medication administration (including missed doses) is fed back into the dosing algorithm. This feedback loop allows the system to continuously adjust and optimize the dosing schedule based on real-world adherence patterns, improving dosing accuracy over time.

Inventive Principle:
Principle #23Feedback

2Adaptability or versatility

If healthcare providers manually adjust dosing schedules for missed doses, then individualized care can be provided, but this process is time-consuming and reduces productivity

Engineering Contradiction:
Improvedosing schedule adaptabilityVSAvoidprovider time efficiency
Core Design Contradiction:
Adaptability or versatilityVSProductivity

Solution Approach 1:

The patent replaces the manual mechanical process of dose calculation with an automated computer-based system. The processor executes algorithms to automatically determine adjusted dosing schedules, substituting human cognitive and calculation efforts with automated computational processes, thereby freeing up provider time while maintaining adaptability.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The system dynamically changes dosing parameters (timing, amount, frequency) based on input variables such as missed doses, patient adherence patterns, and pharmacokinetic properties. This automated parameter adjustment maintains the adaptability previously requiring manual provider intervention while significantly improving productivity.

Inventive Principle:
Principle #35Parameter changes

3Ease of operation

If standardized dosing protocols are used, then ease of operation is improved, but the ability to handle individual patient variations and missed doses is reduced

Engineering Contradiction:
Improvedosing protocol simplicityVSAvoidindividualized dose adjustment
Core Design Contradiction:
Ease of operationVSAdaptability or versatility

Solution Approach 1:

The dosing system transitions from static standardized protocols to dynamic adaptive scheduling. The system automatically adjusts dosing parameters in real-time based on patient-specific factors and adherence behavior, maintaining ease of operation through automation while achieving the adaptability of individualized care through algorithmic personalization.

Inventive Principle:
Principle #15Dynamics

Data Source

PatentEP3826700B1Method of adjusting medication doses
Publication Date: 2026.05.13 SANOFI SA(FR)
  • EP3826700B1 patent drawingFigure 1
  • EP3826700B1 patent drawingFigure 2
  • EP3826700B1 patent drawingFigure 3

AI summary

Method, apparatus and system for adjusting medicament doses. A method of providing a medication dose adjustment using a computing device comprises: receiving an adjustment cycle time period; receiving a threshold number of dose and blood glucose measurement pairs, the threshold number of dose and blood glucose measurement pairs being less than a total number of potential dose and blood glucose measurement pairs possible in the adjustment time cycle period; receiving a dose and blood glucose measurement pair; determining if a total number of dose and blood glucose measurement pairs received within a current adjustment cycle time period meets the threshold number, the current adjustment cycle time period depending on the received adjustment cycle time period; in response to a positive determination, determining if a dose adjustment is required based on the dose and blood glucose measurement pairs received within an adjustment cycle time period; and outputting the dose adjustment.