Melt-Processed Viral Nanoparticle Constructs for Sustained Release
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Solution Overview
Problem
Current biodegradable polymeric devices for drug delivery, such as PLGA, face challenges in providing sustained and controlled release of viral nanoparticles while maintaining their structural and biochemical integrity.
Innovation Solution
A melt-processed viral nanoparticle construct is developed, comprising a degradable polymer matrix and encapsulated virus or virus-like particles. This construct allows for solvent-free processing and controlled release of viral nanoparticles, maintaining their structural and biochemical characteristics.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If biodegradable polymeric devices (PLGA) are used for drug delivery, then sustained and controlled release is achieved, but structural and biochemical integrity of viral nanoparticles is compromised
Solution Approach 1:
The patent changes the processing parameters from conventional solvent-based methods to melt processing at controlled temperatures (below the melting point of PLGA). This parameter change allows sustained release functionality to be maintained while preventing thermal degradation and preserving the structural and biochemical integrity of viral nanoparticles during fabrication
Solution Approach 2:
The patent utilizes the phase transition of PLGA from solid to melt state for processing, then back to solid state for device formation. By controlling this phase transition within specific temperature ranges, the patent achieves both sustained release capability and preservation of viral nanoparticle integrity, avoiding the harmful effects of solvent exposure
2Ease of manufacture
If conventional solvent-based processing is used, then fabrication is easier, but viral nanoparticle integrity is compromised due to solvent exposure
Solution Approach 1:
The patent extracts and eliminates the solvent component from the conventional processing method, transitioning to a solvent-free melt processing approach. This removal of the harmful solvent element maintains fabrication feasibility while preserving the biochemical characteristics of viral particles that would otherwise be degraded by organic solvents
Solution Approach 2:
The patent introduces controlled temperature as an intermediary mechanism to enable processing without solvents. By using thermal energy as the mediating factor to achieve mixing and device formation, the patent avoids direct contact between viral nanoparticles and harmful solvents while maintaining manufacturing capability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The melt-processed nanoparticle construct achieves a sustained and controlled release of viral nanoparticles, effectively maintaining their structural and biochemical integrity, and can be administered minimally invasively for therapeutic and agricultural applications.
Implementation Method 1
The virus or virus-like particles can have a release profile from the degradable polymer matrix at least partially defined by the degradation of the degradable polymer material under environmental and/or physiological conditions
Implementation Method 2
The degradable polymer material can be melt processed at a Peclet number of about 5 to about 25. The degradable polymer material can also have a melt temperature below a degradation temperature of the virus or virus-like particles
Data Source
AI summary
A melt processed viral nanoparticle construct for delivery of virus or virus-like particles to a site of interest includes a degradable polymer matrix and a plurality of virus or virus-like particles encapsulated within the degradable polymer matrix. The nanoparticle construct upon administration to the site of interest providing a sustained release of the virus or virus-like particles and/or nanoparticles upon degradation of the polymer matrix.