Membrane-Based Biomolecule Detection Device for Home Diagnostics
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Solution Overview
Problem
There is a need for low-cost, rapid, and personally administrable diagnostic tests for various diseases or conditions that can be performed in a home setting, particularly for diseases like COVID-19, requiring a disposable system for cell lysis, sample amplification, and detection.
Innovation Solution
A device with a three-dimensional membrane-based substrate having specific substances for different analytes, capable of generating signals indicative of their presence, and a detection unit for determining the presence or absence of these analytes, which can be used with a smartphone for results interpretation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional diagnostic testing is used, then detection reliability is improved, but cost and accessibility deteriorate
Solution Approach 1:
The patent employs disposable test devices with integrated substrates, electrodes, and reagents that are discarded after single use. This eliminates the need for expensive, complex equipment while maintaining detection reliability through standardized manufacturing of the disposable components.
Solution Approach 2:
The test device is designed for self-service operation by untrained users at home. The device automatically performs sample processing, analysis, and result generation without requiring professional laboratory equipment or technician intervention, thereby reducing cost while maintaining reliability through built-in quality controls.
2Measurement precision
If complex diagnostic systems are used, then detection precision is improved, but device complexity deteriorates
Solution Approach 1:
The patent merges multiple functions (sample processing, amplification, detection, and result display) into a single integrated device. This consolidation maintains detection precision while reducing overall system complexity by eliminating the need for separate laboratory equipment for each function.
Solution Approach 2:
The test device is designed as a universal platform that can detect multiple analytes and provide comprehensive diagnostic information through a single device, rather than requiring multiple specialized instruments. This multi-functionality maintains precision across different tests while simplifying the device architecture.
3Difficulty of detecting and measuring
If professional laboratory testing is used, then signal detection accuracy is improved, but ease of operation deteriorates
Solution Approach 1:
The patent replaces complex mechanical and manual signal detection methods with automated electronic detection systems integrated into the device. Optical sensors, electrical contacts, and digital processing automatically detect and interpret signals, maintaining laboratory-grade accuracy while enabling operation by untrained users.
Solution Approach 2:
The device incorporates intermediary components such as amplification reagents, signal transducers, and digital interfaces that bridge the gap between the biological sample and the final readable result. These intermediaries enhance signal detection accuracy while simplifying the user interface for ease of operation.
Data Source
AI summary
The present disclosure provides methods and systems for detecting a presence or absence of analytes. The systems may comprise membrane-based substrates.