Membrane Heat Exchanger for CRRT Blood Temperature Control

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Solution Overview

Problem

Continuous renal replacement therapy (CRRT) experiences significant heat loss from extracorporeally circulated blood due to diffusion or convection to surrounding fluids, leading to patient hypothermia, especially during low blood flow rates, and existing solutions struggle to efficiently heat treatment fluids without direct contact or excessive temperature increase.

Innovation Solution

A heat exchanger with multiple fluid circuits and membranes is used to recover heat from effluent fluid and transfer it to treatment fluids, maintaining blood temperature by alternatingly heating multiple secondary fluids with a primary fluid, thereby reducing heat loss from the extracorporeal circuit.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If treatment fluids are stored sterile in flexible bags or rigid containers, then fluid sterility and integrity are maintained, but heating the treatment fluid becomes challenging without direct contact devices

Engineering Contradiction:
Improvefluid sterilityVSAvoidheating capability
Core Design Contradiction:
ReliabilityVSEase of manufacture

Solution Approach 1:

The patent introduces a heat exchanger as an intermediary device that enables indirect heating of treatment fluids through thermal conduction via the blood circuit components. The blood warmer acts as a mediator between the heat source and the treatment fluid, allowing heating without direct contact between the heating element and the sterile fluid, thus maintaining sterility while achieving the desired temperature increase.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Temperature

If treatment fluid temperature is increased to compensate for heat loss, then blood temperature can be maintained, but the temperature may exceed the safe limit of 41°C

Engineering Contradiction:
Improveblood temperatureVSAvoidexcessive temperature
Core Design Contradiction:
TemperatureVSObject-affected harmful factors

Solution Approach 1:

The patent employs parameter changes by dynamically adjusting the heating parameters based on blood flow rate and temperature measurements. The system monitors blood temperature and flow rate, then modulates the heating power accordingly to maintain blood temperature within the safe range (37-41°C) without exceeding the maximum safe temperature limit, thus preventing thermal damage while compensating for heat loss.

Inventive Principle:
Principle #35Parameter changes

3Loss of energy

If heat is recovered from effluent fluid to heat treatment fluids, then heat loss from blood is reduced, but the temperature of treatment fluids must be carefully controlled

Engineering Contradiction:
Improveheat lossVSAvoidtemperature control
Core Design Contradiction:
Loss of energyVSDevice complexity

Solution Approach 1:

The patent implements feedback control by continuously monitoring the temperature of both the effluent fluid and the treatment fluid, as well as the blood flow rate. The system uses this feedback information to dynamically adjust the heating process in the heat exchanger, ensuring that heat is recovered efficiently from the effluent while preventing the treatment fluid from exceeding the safe temperature limit of 41°C, thus balancing energy recovery with temperature control.

Inventive Principle:
Principle #23Feedback

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The heat exchanger effectively recovers heat from effluent fluid and transfers it to treatment fluids, maintaining blood temperature across varying blood flow rates, reducing heat loss and preventing patient hypothermia while ensuring treatment fluid temperatures do not exceed 41°C.

Implementation Method 1

exchanging heat between a primary fluid and at least a first secondary fluid

Methodology Applied
Scientific EffectHeat transfer: Conduction (thermal)

Implementation Method 2

a stack of fluid plates and a membrane arranged between each of the fluid plates such that one interspace is formed between one side of a fluid plate and one side of a membrane

Methodology Applied
Scientific EffectThermal conduction through membrane: Conduction (thermal)

Data Source

PatentEP2349391B1Heat exchanger and method for heat exchanging
Publication Date: 2016.07.27 GAMBRO LUNDIA AB
  • EP2349391B1 patent drawingFigure 1
  • EP2349391B1 patent drawingFigure 2a
  • EP2349391B1 patent drawingFigure 2b

AI summary

The present invention relates to a method for exchanging heat between an effluent fluid (4) and a treatment fluid (5, 7, 9) and a heat exchanger (11) for heat exchange as well as an arrangement and a kit comprising a heat exchanger. The heat exchanger comprises a first and a second fluid circuit (19, 20) extending through the heat exchanger. The heat exchanger further comprises a stack of fluid plates (12, 13, 40) and a membrane (16) arranged between each of the fluid plates (12, 13, 40) where one interspace is formed between each fluid plate and membrane. The first and the second fluid circuit (19, 20) is each constituted by a passage extending through the fluid plates and membranes and along the fluid plates and membranes in at least two interspaces (17, 18). According to the method for heat exchanging an effluent fluid (4) is passed through the first fluid circuit (19) and a treatment fluid (5, 7, 9) is passed through the second fluid circuit (20) such that the effluent fluid (4) is passed along one side of a membrane (16) and simultaneously the treatment fluid (5, 7, 9) is passed along the other side of the membrane (16). Heat is thus exchanged between the effluent fluid (4) and the treatment fluid (5, 7, 9) over the membrane (16).