Cell Membrane Nanoparticles With Isotonic Core Stability
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Solution Overview
Problem
Existing nanoparticles do not effectively utilize cellular membranes to create a stable and isotonic interior compartment for therapeutic delivery, and there is a need for enhanced cellular membrane-based nanoparticles with enriched steroid levels for targeted disease treatment.
Innovation Solution
The development of nanoparticles with an interior compartment that is isotonic to cellular or physiological liquids and an outer surface enriched with cellular membranes, particularly from red blood cells, using processes that include contacting cellular membranes with steroids and sphingolipids to enhance stability and functionality.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing nanoparticles are used without cellular membrane enrichment, then the structure is simpler and easier to manufacture, but the stability and therapeutic delivery effectiveness are insufficient
Solution Approach 1:
The patent combines cellular membranes with nanoparticle cores to create composite structures. The cellular membrane is enveloped around a nanoparticle core, forming a hybrid material that integrates the biocompatibility and targeting capabilities of cellular membranes with the controlled delivery properties of synthetic nanoparticles, thereby enhancing therapeutic delivery effectiveness while maintaining manufacturability
Solution Approach 2:
The patent enriches specific regions of the nanoparticle structure with cellular membrane components, particularly steroids and sphingolipids, at the membrane-nanoparticle interface. This localized enrichment enhances membrane stability and therapeutic delivery at critical locations without requiring complete restructuring of the entire nanoparticle system
2Stability of the object's composition
If cellular membranes are not enriched with steroids and sphingolipids, then the manufacturing process is simpler, but the membrane stability is insufficient for effective therapeutic delivery
Solution Approach 1:
The patent incorporates steroids and sphingolipids into the cellular membrane structure during the nanoparticle formation process. By pre-enriching the membrane with these stabilizing components before therapeutic cargo loading, the method ensures enhanced membrane stability without requiring additional complex post-manufacturing steps, thus maintaining ease of manufacture while achieving improved stability
Solution Approach 2:
The patent modifies the chemical composition parameters of the cellular membrane by enriching it with specific concentrations of steroids and sphingolipids. This parameter change enhances the physical and chemical stability of the membrane structure, improving its ability to maintain integrity during therapeutic delivery while the enrichment process remains integrated into existing manufacturing protocols
3Adaptability or versatility
If the interior compartment is not isotonic to cellular liquid, then the nanoparticle structure is simpler, but the compatibility with cellular environments and therapeutic efficacy are reduced
Solution Approach 1:
The patent adjusts the osmotic pressure parameter of the interior compartment to match that of cellular liquid, creating an isotonic environment. This parameter matching enhances the nanoparticle's adaptability to cellular environments, improving therapeutic efficacy by preventing osmotic stress on delivered cargo while the isotonic formulation remains compatible with standard nanoparticle manufacturing approaches
Data Source
AI summary
The present disclosure relates to nanoparticles containing cellular membrane and uses thereof. The nanoparticle comprises an interior compartment (or an inner core) and an outer surface (or shell) comprising a cellular membrane derived from a cell, said interior compartment (or an inner core) not providing a solid support to said cellular membrane in said outer surface (or shell). The present disclosure also relates to processes of making the nanoparticles. The present disclosure further relates to compositions comprising the nanoparticles and methods of using the nanoparticles.