Menstrual Pain Dermal Patch Using Penetration Enhancers
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Solution Overview
Problem
Current dermal patches for menstrual pain relief often lack effective delivery mechanisms for anti-pain drugs, particularly for primary and secondary dysmenorrhea, and may include unwanted additives like opioids, muscle relaxants, or corticosteroids.
Innovation Solution
A pharmaceutical formulation comprising capsaicin, eugenol, cannabidiol, and β-caryophyllene, with penetration enhancers like azone and oleic acid, integrated into monolithic or reservoir-style dermal patches using polyisobutylene, polydimethylsiloxane, or polyacrylate adhesives, specifically designed to reduce menstrual pain without certain excluded drug classes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional dermal patches are used for menstrual pain relief, then they can provide pain relief, but they lack effective delivery mechanisms for anti-pain drugs and may include unwanted additives
Solution Approach 1:
The patent changes the chemical parameters of the formulation by incorporating specific penetration enhancers (azone, oleic acid) alongside the active ingredients (capsaicin, eugenol, cannabidiol, β-caryophyllene). This modification enhances the delivery mechanism's effectiveness without adding structural complexity to the patch itself.
Solution Approach 2:
The patent uses composite adhesive materials (polyisobutylene, polydimethylsiloxane, or polyacrylate) that combine bonding functionality with drug delivery capabilities. This composite approach provides effective pain relief through enhanced skin penetration while maintaining a relatively simple patch structure.
2Speed
If penetration enhancers are added to improve drug delivery, then skin penetration of active ingredients is enhanced, but the formulation complexity increases
Solution Approach 1:
The patent modifies the formulation's chemical parameters by adding penetration enhancers (azone, oleic acid) that change the physical-chemical properties of the drug-delivery system. This enables faster skin penetration through altered solubility and permeability characteristics without requiring complex delivery devices.
Solution Approach 2:
The penetration enhancers act as intermediary substances that facilitate the transfer of active ingredients through the skin barrier. These mediators (azone, oleic acid) temporarily interact with the skin structure to enable faster drug penetration, then are eliminated, leaving no unwanted additives in the body.
3Reliability
If multiple active ingredients are combined for enhanced pain relief, then the therapeutic effect is improved, but the risk of including unwanted additives increases
Solution Approach 1:
The patent extracts and eliminates unwanted additives (opioids, muscle relaxants, corticosteroids) from the formulation while retaining only the essential active ingredients (capsaicin, eugenol, cannabidiol, β-caryophyllene) and safe penetration enhancers. This extraction approach provides effective pain relief without exposing patients to harmful substances.
Solution Approach 2:
The patent applies local quality by giving each ingredient a specific, controlled function: capsaicin and eugenol provide analgesic effects, cannabidiol and β-caryophyllene contribute to pain relief through different mechanisms, and penetration enhancers (azone, oleic acid) are limited to their temporary role in facilitating skin penetration. This precise functional assignment ensures therapeutic effectiveness while eliminating unwanted systemic effects.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation effectively reduces menstrual pain by enhancing skin penetration of active ingredients, providing rapid pain relief and improving quality of life scores, as measured by Visual Analogue Scale and Quality of Life Scale assessments, while excluding opioids and other unwanted drugs.
Implementation Method 1
The formulation further comprises a penetration enhancer... said penetration enhancer is one or more of either azone, oleic acid
Implementation Method 2
The permeable membrane is optionally coated with an adhesive that mediates binding of the adhesive to the skin
Implementation Method 3
a hydrogel, a semisolid three-dimensional, crosslinked networks of synthetic and natural water-soluble polymers
Data Source
AI summary
The disclosure provides monolithic-style dermal patches and reservoir-style dermal patches, where the dermal patch is capable of delivering a mixture of anti-pain drugs to the skin. Provided also are methods for manufacturing said dermal patches.