Mesh Filter for Bubble-Free Dissolution of Lyophilized Reagents
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Solution Overview
Problem
Existing disposable cartridges face challenges in handling lyophilized reagents due to static electricity, incomplete dissolution, and air bubbles, leading to inconsistent reagent concentration and increased contamination risk.
Innovation Solution
A mesh filter with a lyophilized material fixed to its mesh is integrated into a fluid handling device, allowing for efficient dissolution of the reagent by rotating the housing part to align chambers with syringe insertion, ensuring complete dissolution without air bubbles.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If lyophilized material is placed in a chamber and liquid is filled to dissolve it, then reagent preparation is achieved, but the lyophilized material may not be placed at the bottom due to static electricity, leading to incomplete dissolution and air bubbles
Solution Approach 1:
A mesh filter is introduced as an intermediary component to hold the lyophilized material. The mesh filter serves as a mediator between the lyophilized material and the chamber, preventing direct contact issues while enabling controlled dissolution. The mesh structure allows liquid to pass through and contact the lyophilized material uniformly, ensuring complete dissolution without air bubbles.
Solution Approach 2:
The mesh filter utilizes a porous structure with specific aperture sizes (5μm to 500μm) to achieve both filtration and dissolution functions. The porous nature allows liquid to penetrate through the mesh and reach the lyophilized material from multiple directions, ensuring uniform and complete dissolution while preventing air bubble formation.
2Reliability
If a large amount of liquid is used to ensure complete dissolution, then dissolution efficiency improves, but reagent concentration control becomes difficult
Solution Approach 1:
The mesh filter's controlled porosity and aperture size (5μm to 500μm) regulate liquid flow through the lyophilized material. This controlled flow ensures sufficient liquid contact for complete dissolution while preventing excessive liquid intake, thereby maintaining precise reagent concentration.
Solution Approach 2:
The mesh filter acts as a standardized component that can be replicated with precise aperture specifications. By using a mesh with defined pore sizes, the system achieves consistent dissolution behavior across multiple uses, ensuring both complete dissolution and accurate concentration control.
3Speed
If lyophilized material is produced by dropping into liquid nitrogen, then rapid freezing is achieved, but quantification becomes difficult and contamination risk increases
Solution Approach 1:
The mesh filter is designed as a disposable component that can be pre-loaded with lyophilized material in a controlled environment. This eliminates the need for dangerous liquid nitrogen handling during normal operation, reducing contamination risks while maintaining rapid freezing capabilities during manufacturing.
Solution Approach 2:
The mesh filter serves as an intermediary that allows safe handling and storage of lyophilized material. By containing the material on the mesh, the system avoids direct exposure to contamination risks associated with liquid nitrogen operations, while still achieving rapid freezing during the manufacturing phase.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The mesh filter provides excellent handleability and efficient dissolution of lyophilized materials, ensuring consistent reagent concentration and reducing contamination risks.
Implementation Method 1
a mesh filter configured to be detachable with respect to the housing part... efficient dissolution of the reagent by rotating the housing part to align chambers with syringe insertion
Data Source
AI summary
The present invention provides a mesh filter having superior handling performance for liquid-solution lyophilizates. This mesh filter 130 has a mesh 131, and liquid-solution lyophilizates 132 affixed to the mesh.