Mesh Nebulizer Kit for Faster High-Dose Pulmonary Delivery

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Solution Overview

Problem

Nebulizers face challenges with long delivery times for high-dose medications, necessitating a need for improved drug delivery efficiency and reduced inhalation time to enhance treatment convenience and compliance.

Innovation Solution

A nebulizer kit comprising a pharmaceutical composition with prostaglandin, prostaglandin analogue, or prostacyclin analogue, and a nebulizer with a mesh and breath-activated sensor, configured to deliver about 5 to 600 μg of the drug in less than 3 minutes with a delivery efficiency higher than 50%.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If nebulizers are used to deliver high-dose medications, then drug delivery efficiency to pulmonary region is improved, but delivery time becomes excessively long

Engineering Contradiction:

Improvedrug delivery efficiencyVSAvoiddelivery time

Core Design Contradiction:

ProductivityVSLoss of time

Solution Approach 1:

The patent changes the physical-chemical parameters of the pharmaceutical composition by incorporating liposomes with specific size ranges (0.1-10 μm) and using co-solvents at optimized concentrations. These parameter changes enable the formulation to be delivered efficiently through mesh nebulization, achieving both high drug delivery efficiency to the pulmonary region and reduced delivery time compared to conventional nebulizer formulations.

Inventive Principle:

Principle #35Parameter changes

2Quantity of substance

If conventional nebulization methods are used, then treatment dosage can be maintained, but treatment convenience and long-term compliance deteriorate due to long delivery times

Engineering Contradiction:

Improvetreatment dosageVSAvoidtreatment convenience

Core Design Contradiction:

Quantity of substanceVSEase of operation

Solution Approach 1:

The patent replaces the conventional jet or ultrasonic nebulization mechanism with a mesh-based pneumatic nebulization system. This substitution allows for more efficient aerosol generation with smaller particle sizes that can be delivered rapidly to the pulmonary region, maintaining the required treatment dosage while significantly reducing delivery time and improving patient compliance.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent uses a composite pharmaceutical formulation consisting of liposomes encapsulating prostaglandin or prostacyclin analogues, combined with specific co-solvents and surfactants. This composite material system enables stable, efficient nebulization while maintaining the therapeutic dosage, thereby improving treatment convenience without compromising the quantity of active substance delivered.

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The kit achieves rapid drug delivery with enhanced efficiency, improving treatment convenience and compliance for respiratory diseases and heart failure.

Implementation Method 1

Aerosols can be produced by different techniques, classified into three main categories: nebulizers (jet, ultrasonic, non-ultrasonic, and vibrating mesh)

Methodology Applied

Scientific EffectNebulization:

Implementation Method 2

a nebulizer, comprising a mesh, a breath-activated sensor, and a reservoir

Methodology Applied

Scientific EffectBreath detection:

Data Source

PatentUS20260069535A1Nebulizer kits and uses thereof

Publication Date: 2026.03.12 PHARMOSA BIOPHARM INC

AI summary

The present invention relates to a nebulizer kit, comprising a pharmaceutical composition including a prostaglandin, prostacyclin and the analogue thereof and a nebulizer to deliver a prostaglandin, prostaglandin analogue, prostacyclin or prostacyclin analogue with a higher drug delivery efficiency. Also disclosed are methods for treating a respiratory disease and heart failure, using the nebulizer kit disclosed herein.