Meshed Acellular Dermal Matrix for Implant Conformability
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Solution Overview
Problem
Existing acellular dermal matrix (ADM) products face challenges in conforming to the shape of tissue implants and surrounding anatomic structures without wrinkling or deformation, and in evenly distributing tension when surgically anchored, particularly due to complex contours and convex/concave curves.
Innovation Solution
Development of meshed acellular tissue matrix compositions with slits forming a regular pattern, allowing for expansion and contraction to conform to various shapes, providing even tension distribution and fluid drainage, while preventing fibrous capsule formation around implants.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If a flat sheet ADM product is used, then the product provides a simple structure and easy handling, but it cannot conform to complex anatomical structures and implants without wrinkling or deformation
Solution Approach 1:
The ADM product is divided into multiple segments by creating a mesh pattern with openings throughout the sheet. This segmentation allows each segment to independently conform to complex anatomical contours and implant shapes, eliminating wrinkling and deformation while maintaining overall structural integrity.
Solution Approach 2:
The meshed ADM product functions as a flexible thin film structure that can drapely conform to three-dimensional anatomical surfaces and implant contours. The flexible mesh configuration allows the product to adapt to complex geometries without rigid structural constraints.
2Ease of operation
If a solid ADM sheet is used, then the product provides uniform tissue coverage, but it creates concentrated tension at anchor points and cannot provide fluid drainage
Solution Approach 1:
The solid sheet is segmented into a mesh pattern with multiple openings, which distributes surgical anchor points across multiple segments rather than concentrating tension at single points. This segmentation prevents localized tissue damage and reduces deformation risk while maintaining secure anchoring.
Solution Approach 2:
The meshed ADM product incorporates a porous structure with openings that facilitate fluid drainage and reduce tissue edema. The porous configuration allows for even tension distribution across the anchoring sites while maintaining structural support and preventing deformation.
3Adaptability or versatility
If a meshed ADM product is used, then the product can conform to complex shapes and provide fluid drainage, but it may allow fibrous capsule formation around implants
Solution Approach 1:
The mesh configuration is designed with specific opening sizes and patterns that vary locally to optimize both conformability and anti-capsule properties. The local quality of the mesh structure allows for shape adaptation while the specific geometric characteristics prevent fibrous capsule formation through controlled tissue integration.
Data Source
AI summary
The present disclosure provides meshed acellular dermal tissue matrix compositions, devices, and methods of use. The meshed devices can be used in conjunction with a variety of implants such as breast implants or tissue expanders.